id:"swepub:oai:gup.ub.gu.se/217394"
Sökning: id:"swepub:oai:gup.ub.gu.se/217394" > Lipid Structural Ef...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03741naa a2200373 4500 | |
| 001 | oai:gup.ub.gu.se/217394 | |
| 003 | SwePub | |
| 008 | 240528s2015 | |||||||||||000 ||eng| | |
| 009 | oai:research.chalmers.se:fb7c88cb-2151-4afe-8614-580292b4d189 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2173942 URI |
| 024 | 7 | a https://doi.org/10.1021/acs.analchem.5b005552 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/2173942 URI |
| 040 | a (SwePub)gud (SwePub)cth | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Phan, Nhu TN,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xphant |
| 245 | 1 0 | a Lipid Structural Effects of Oral Administration of Methylphenidate in Drosophila Brain by Secondary Ion Mass Spectrometry Imaging |
| 264 | c 2015-04-13 | |
| 264 | 1 | b American Chemical Society (ACS),c 2015 |
| 338 | a electronic2 rdacarrier | |
| 520 | a We use time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging to investigate the effects of orally administrated methylphenidate on lipids in the brain of Drosophila melanogaster (fruit fly), a major invertebrate model system in biological study and neuroscience. TOF-SIMS imaging was carried out using a recently designed high energy 40 keV Ar-4000(+) gas cluster ion gun which demonstrated improved sensitivity for intact lipids in the fly brain compared to the 40 keV C-60(+) primary ion gun. In addition, correlation of TOF-SIMS and SEM imaging on the same fly brain showed that there is specific localization that is related to biological functions of various biomolecules. Different lipids distribute in different parts of the brain, central brain, optical lobes, and proboscis, depending on the length of the carbon chain and saturation level of fatty acid (FA) branches. Furthermore, data analysis using image principal components analysis (PCA) showed that methylphenidate dramatically affected both the distribution and abundance of lipids and their derivatives, particularly fatty acids, diacylglycerides, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol in the fly brains. Our approach using TOF-SIMS imaging successfully visualizes the effects of methylphenidate on the chemical structure of the fly brain. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
| 700 | 1 | a Fletcher, John S.u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)fletcher |
| 700 | 1 | a Ewing, Andrew G,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)andrewe |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Analytical Chemistryd : American Chemical Society (ACS)g 87:8, s. 4063-4071q 87:8<4063-4071x 0003-2700x 1520-6882 |
| 856 | 4 | u https://gup.ub.gu.se/publication/217394x primaryx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1021/acs.analchem.5b00555y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/217394 |
| 856 | 4 8 | u https://doi.org/10.1021/acs.analchem.5b00555 |
| 856 | 4 8 | u https://research.chalmers.se/publication/217394 |
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