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Quantification of total apolipoprotein E and its specific isoforms in cerebrospinal fluid and blood in Alzheimer's disease and other neurodegenerative diseases
- Rezeli, M. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Laurell, T. (author)
- Hansson, O. (author)
- Marko-Varga, G. (author)
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- (creator_code:org_t)
- Elsevier, 2015
- 2015
- English.
- In: EuPA Open Proteomics. - : Elsevier. - 2212-9685. ; 8, s. 137-143
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A targeted mass spectrometric assay was developed for identification and quantification of apoE isoforms (apoE2, E3 and E4), and it was utilized for screening of samples from AD patients (. n=. 39) and patients with other neurodegenerative disorders (. n=. 38). The assay showed good linearity with LOQ corresponds to total apoE concentration of 0.8 and 40. ng/mL in CSF and plasma/serum, respectively. We identified apoE phenotypes with 100% accuracy in clinical samples. We found strong association between genotypes of the individuals and their apoE levels in blood; ε4 allele carriers had significantly lower apoE levels in blood than non-carriers. © 2015.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- ApoE
- CSF biomarkers
- Protein isoforms
- SRM
- apolipoprotein E
- apolipoprotein E2
- apolipoprotein E3
- apolipoprotein E4
- isoprotein
- adult
- aged
- allele
- Alzheimer disease
- Article
- controlled study
- degenerative disease
- female
- genotype
- human
- human tissue
- major clinical study
- male
- mass spectrometry
- measurement accuracy
- phenotype
- priority journal
- protein analysis
- protein blood level
- protein cerebrospinal fluid level
- screening
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Marko-Varga, G.
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- MEDICAL AND HEALTH SCIENCES
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- University of Gothenburg
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