Feasibility of quantitative determination of doxorubicin with surface-enhanced Raman spectroscopy

Lorén, Anders, 1974 (author): Chalmers tekniska högskola,Chalmers University of Technology

Eliasson, C. (author)

Josefson, M. (author)

Murty, K.V.G.K. (author)

Käll, Mikael, 1963 (author): Chalmers tekniska högskola,Chalmers University of Technology

Abrahamsson, Jonas, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,University of Gothenburg

Abrahamsson, Katarina, 1957 (author): Chalmers tekniska högskola,Chalmers University of Technology

(creator_code:org_t)

2001-10-24
2001
English.
In: Journal of Raman Spectroscopy. - : Wiley. - 0377-0486 .- 1097-4555. ; 32:11, s. 971-974

Related links:: http://dx.doi.org/10...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://research.cha...; show less...

Abstract Subject headings

Surface-enhanced Raman spectroscopy (SERS) was performed using excitation at 488 nm in a blood plasma-doxorubicin-silver colloid system. With a blood plasma content of 1%, a partial least-squares calibration of the doxorubicin was made in the 10-750 nM range. Predictions for a test set generated a root mean square error of prediction of 70 nM. The use of SERS and chemometrics in complex systems made it possible to use the highly informative Raman signals even at low concentrations without the need for sample pretreatment such as extraction. Copyright © 2001 John Wiley & Sons, Ltd.

By the author/editor: Lorén, Anders, 1 ...; Eliasson, C.; Josefson, M.; Murty, K.V.G.K.; Käll, Mikael, 19 ...; Abrahamsson, Jon ...; show more...; Abrahamsson, Kat ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

By the university: University of Gothenburg; Chalmers University of Technology

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