SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:gup.ub.gu.se/227524"
 

Search: id:"swepub:oai:gup.ub.gu.se/227524" > Fucosylation and pr...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Fucosylation and protein glycosylation create functional receptors for cholera toxin.

Wands, Amberlyn M (author)
Fujita, Akiko (author)
McCombs, Janet E (author)
show more...
Cervin, Jakob (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
Dedic, Benjamin (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
Rodriguez, Andrea C (author)
Nischan, Nicole (author)
Bond, Michelle R (author)
Mettlen, Marcel (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Trudgian, David C (author)
Lemoff, Andrew (author)
Quiding-Järbrink, Marianne, 1964 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Gustavsson, Bengt, 1947 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
Steentoft, Catharina (author)
Clausen, Henrik (author)
Mirzaei, Hamid (author)
Teneberg, Susann, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Yrlid, Ulf, 1971 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Kohler, Jennifer J (author)
show less...
 (creator_code:org_t)
2015
2015
English.
In: eLife. - 2050-084X. ; 4
Related links:
https://gup.ub.gu.se...
show more...
https://doi.org/10.7...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic. Here we report that CTB binds cell surface glycoproteins. Relative contributions of gangliosides and glycoproteins to CTB binding depend on cell type, and CTB binds primarily to glycoproteins in colonic epithelial cell lines. Using a metabolically incorporated photocrosslinking sugar, we identified one CTB-binding glycoprotein and demonstrated that the glycan portion of the molecule, not the protein, provides the CTB interaction motif. We further show that fucosylated structures promote CTB entry into a colonic epithelial cell line and subsequent host cell intoxication. CTB-binding fucosylated glycoproteins are present in normal human intestinal epithelia and could play a role in cholera.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • eLife (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view