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Fucosylation and pr...
Fucosylation and protein glycosylation create functional receptors for cholera toxin.
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Wands, Amberlyn M (author)
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Fujita, Akiko (author)
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McCombs, Janet E (author)
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- Cervin, Jakob (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Dedic, Benjamin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Rodriguez, Andrea C (author)
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Nischan, Nicole (author)
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Bond, Michelle R (author)
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- Mettlen, Marcel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Trudgian, David C (author)
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Lemoff, Andrew (author)
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- Quiding-Järbrink, Marianne, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Gustavsson, Bengt, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Steentoft, Catharina (author)
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Clausen, Henrik (author)
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Mirzaei, Hamid (author)
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- Teneberg, Susann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Yrlid, Ulf, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Kohler, Jennifer J (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: eLife. - 2050-084X. ; 4
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https://doi.org/10.7...
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Abstract
Subject headings
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- Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic. Here we report that CTB binds cell surface glycoproteins. Relative contributions of gangliosides and glycoproteins to CTB binding depend on cell type, and CTB binds primarily to glycoproteins in colonic epithelial cell lines. Using a metabolically incorporated photocrosslinking sugar, we identified one CTB-binding glycoprotein and demonstrated that the glycan portion of the molecule, not the protein, provides the CTB interaction motif. We further show that fucosylated structures promote CTB entry into a colonic epithelial cell line and subsequent host cell intoxication. CTB-binding fucosylated glycoproteins are present in normal human intestinal epithelia and could play a role in cholera.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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eLife
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To the university's database
- By the author/editor
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Wands, Amberlyn ...
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Fujita, Akiko
-
McCombs, Janet E
-
Cervin, Jakob
-
Dedic, Benjamin
-
Rodriguez, Andre ...
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show more...
-
Nischan, Nicole
-
Bond, Michelle R
-
Mettlen, Marcel
-
Trudgian, David ...
-
Lemoff, Andrew
-
Quiding-Järbrink ...
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Gustavsson, Beng ...
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Steentoft, Catha ...
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Clausen, Henrik
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Mirzaei, Hamid
-
Teneberg, Susann ...
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Yrlid, Ulf, 1971
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Kohler, Jennifer ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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eLife
- By the university
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University of Gothenburg