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The toxic effects o...
The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells
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Wang, C. (author)
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Gu, S. (author)
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Yin, X. Q. (author)
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Yuan, M. M. (author)
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- Xiang, Zou (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Li, Z. T. (author)
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Cao, H. H. (author)
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Meng, X. N. (author)
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Hu, K. B. (author)
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Han, X. D. (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Toxicon. - : Elsevier BV. - 0041-0101. ; 115, s. 81-88
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Abstract
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- Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Microcystin-LR
- Chronic low dose
- Lung
- Toxic
- mesenchymal transition
- inhibition
- mechanisms
- surfactant
- liver
- water
- line
- cyanotoxins
- metastasis
- activation
- Pharmacology & Pharmacy
- Toxicology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Toxicon
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- By the author/editor
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Wang, C.
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Gu, S.
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Yin, X. Q.
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Yuan, M. M.
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Xiang, Zou
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Li, Z. T.
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show more...
-
Cao, H. H.
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Meng, X. N.
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Hu, K. B.
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Han, X. D.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Toxicon
- By the university
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University of Gothenburg