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The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells
- Wang, C. (author)
- Gu, S. (author)
- Yin, X. Q. (author)
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- Yuan, M. M. (author)
- Li, Z. T. (author)
- Cao, H. H. (author)
- Meng, X. N. (author)
- Hu, K. B. (author)
- Han, X. D. (author)
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- (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
- In: Toxicon. - : Elsevier BV. - 0041-0101. ; 115, s. 81-88
- Journal article (peer-reviewed)
Abstract
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- Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Microcystin-LR
- Chronic low dose
- Lung
- Toxic
- mesenchymal transition
- inhibition
- mechanisms
- surfactant
- liver
- water
- line
- cyanotoxins
- metastasis
- activation
- Pharmacology & Pharmacy
- Toxicology
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- ref (subject category)
- art (subject category)
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- By the author/editor
- Wang, C.
- Gu, S.
- Yin, X. Q.
- Yuan, M. M.
- Xiang, Zou
- Li, Z. T.
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- Cao, H. H.
- Meng, X. N.
- Hu, K. B.
- Han, X. D.
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Toxicon
- By the university
- University of Gothenburg
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