Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Li, S. S. (author)

Zhu, A. (author)

Benes, V. (author)

Costea, P. I. (author)

Hercog, R. (author)

Hildebrand, F. (author)

Huerta-Cepas, J. (author)

Nieuwdorp, Max (author): Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory

Salojarvi, J. (author)

Voigt, A. Y. (author)

Zeller, G. (author)

Sunagawa, S. (author)

de Vos, W. M. (author)

Bork, P. (author)

(creator_code:org_t)

American Association for the Advancement of Science (AAAS), 2016
2016
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 352:6285, s. 586-589

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.

By the author/editor: Li, S. S.; Zhu, A.; Benes, V.; Costea, P. I.; Hercog, R.; Hildebrand, F.; show more...; Huerta-Cepas, J.; Nieuwdorp, Max; Salojarvi, J.; Voigt, A. Y.; Zeller, G.; Sunagawa, S.; de Vos, W. M.; Bork, P.; show less...

About the subject

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