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Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis
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- Eriksson, Charlotta, 1986 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Studahl, Marie, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
- (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
- In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728. ; 295, s. 130-138
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Herpes simplex encephalitis (HSE) is characterized by a pronounced inflammatory activity in the central nervous system (CNS). Here, we investigated the acute and prolonged complement system activity in HSE patients, by using enzyme-linked immunosorbent assays (ELISAs) for numerous complement components (C). We found increased cerebrospinal fluid concentrations of C3a, C3b, C5 and C5a in HSE patients compared with healthy controls. C3a and C5a concentrations remained increased also compared with patient controls. Our results conclude that the complement system is activated in CNS during HSE in the acute phase, and interestingly also in later stages supporting previous reports of prolonged inflammation. (C) 2016 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Complement activation
- Herpes simplex virus type 1
- Herpes simplex encephalitis
- Central nervous system infection
- Anaphylatoxins
- glycoprotein-c
- virus
- brain
- c3a
- pathogenesis
- multicenter
- meningitis
- infections
- acyclovir
- diagnosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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