Sökning: id:"swepub:oai:gup.ub.gu.se/254049" > Localization of Sta...
Fältnamn | Indikatorer | Metadata |
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000 | 05224naa a2200697 4500 | |
001 | oai:gup.ub.gu.se/254049 | |
003 | SwePub | |
008 | 240528s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:135658300 | |
009 | oai:DiVA.org:liu-137392 | |
024 | 7 | a https://gup.ub.gu.se/publication/2540492 URI |
024 | 7 | a https://doi.org/10.1186/s12866-017-0997-32 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1356583002 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1373922 URI |
040 | a (SwePub)gud (SwePub)kid (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hanssen, A. M.u UiT Arctic University of Norway, Norway4 aut |
245 | 1 0 | a Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers |
264 | c 2017-04-05 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|Norwegian Research Council (NFR) [191, 264]; Northern Norway Regional Health Authority (Helse Nord RHF) [SFP877-09]; Miljostotte [MIL963-10]; UiT The Arctic University of Norway | |
520 | a Background: Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. Methods: Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non-/intermittent carriers, n = 39) attending the population-based Tromso 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope. Results: Our results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected. Conclusions: Knowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
653 | a Nasal colonization | |
653 | a Staphylococcus aureus | |
653 | a Carrier | |
653 | a Localization | |
653 | a Epithelial cells | |
653 | a Intracellular | |
653 | a BACTERIAL ADHERENCE | |
653 | a EPITHELIAL-CELLS | |
653 | a SKIN MICROBIOME | |
653 | a CARRIAGE | |
653 | a COLONIZATION | |
653 | a DECOLONIZATION | |
653 | a DETERMINANTS | |
653 | a ADHESION | |
653 | a INTERNALIZATION | |
653 | a RHINOSINUSITIS | |
653 | a Nasal colonization; Staphylococcus aureus; Carrier; Localization; Epithelial cells; Intracellular | |
700 | 1 | a Kindlund, Bert,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xkinbe |
700 | 1 | a Stenklev, N. C.u UiT Arctic University of Norway, Norway4 aut |
700 | 1 | a Furberg, A. S.u University Hospital North Norway, Norway; UiT Arctic University of Norway, Norway4 aut |
700 | 1 | a Fismen, S.u University Hospital North Norway, Norway4 aut |
700 | 1 | a Slind Olsen, Renateu Linköpings universitet,Karolinska Institutet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Department Lab Med, Sweden4 aut0 (Swepub:liu)rensl63 |
700 | 1 | a Johannessen, M.u UiT Arctic University of Norway, Norway4 aut |
700 | 1 | a Sollid, J. U. E.u UiT Arctic University of Norway, Norway4 aut |
710 | 2 | a UiT Arctic University of Norway, Norwayb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
773 | 0 | t BMC Microbiologyd : Springer Science and Business Media LLCg 17q 17x 1471-2180 |
856 | 4 | u https://gup.ub.gu.se/publication/254049x primaryx freey FULLTEXT |
856 | 4 | u https://doi.org/10.1186/s12866-017-0997-3 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1096682/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/254049 |
856 | 4 8 | u https://doi.org/10.1186/s12866-017-0997-3 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135658300 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137392 |
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