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FältnamnIndikatorerMetadata
00005224naa a2200697 4500
001oai:gup.ub.gu.se/254049
003SwePub
008240528s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:135658300
009oai:DiVA.org:liu-137392
0247 a https://gup.ub.gu.se/publication/2540492 URI
0247 a https://doi.org/10.1186/s12866-017-0997-32 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1356583002 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1373922 URI
040 a (SwePub)gud (SwePub)kid (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hanssen, A. M.u UiT Arctic University of Norway, Norway4 aut
2451 0a Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers
264 c 2017-04-05
264 1b Springer Science and Business Media LLC,c 2017
338 a electronic2 rdacarrier
500 a Funding Agencies|Norwegian Research Council (NFR) [191, 264]; Northern Norway Regional Health Authority (Helse Nord RHF) [SFP877-09]; Miljostotte [MIL963-10]; UiT The Arctic University of Norway
520 a Background: Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. Methods: Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non-/intermittent carriers, n = 39) attending the population-based Tromso 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope. Results: Our results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected. Conclusions: Knowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a Nasal colonization
653 a Staphylococcus aureus
653 a Carrier
653 a Localization
653 a Epithelial cells
653 a Intracellular
653 a BACTERIAL ADHERENCE
653 a EPITHELIAL-CELLS
653 a SKIN MICROBIOME
653 a CARRIAGE
653 a COLONIZATION
653 a DECOLONIZATION
653 a DETERMINANTS
653 a ADHESION
653 a INTERNALIZATION
653 a RHINOSINUSITIS
653 a Nasal colonization; Staphylococcus aureus; Carrier; Localization; Epithelial cells; Intracellular
7001 a Kindlund, Bert,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xkinbe
7001 a Stenklev, N. C.u UiT Arctic University of Norway, Norway4 aut
7001 a Furberg, A. S.u University Hospital North Norway, Norway; UiT Arctic University of Norway, Norway4 aut
7001 a Fismen, S.u University Hospital North Norway, Norway4 aut
7001 a Slind Olsen, Renateu Linköpings universitet,Karolinska Institutet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Department Lab Med, Sweden4 aut0 (Swepub:liu)rensl63
7001 a Johannessen, M.u UiT Arctic University of Norway, Norway4 aut
7001 a Sollid, J. U. E.u UiT Arctic University of Norway, Norway4 aut
7102 a UiT Arctic University of Norway, Norwayb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org
7730 t BMC Microbiologyd : Springer Science and Business Media LLCg 17q 17x 1471-2180
8564 u https://gup.ub.gu.se/publication/254049x primaryx freey FULLTEXT
8564 u https://doi.org/10.1186/s12866-017-0997-3
8564 u https://liu.diva-portal.org/smash/get/diva2:1096682/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/254049
8564 8u https://doi.org/10.1186/s12866-017-0997-3
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135658300
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137392

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