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The role of hydroph...
The role of hydrophobicity in tuberculosis evolution and pathogenicity
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Jankute, M. (författare)
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Nataraj, V. (författare)
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Lee, O. Y. C. (författare)
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Wu, H. H. T. (författare)
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- Ridell, Malin, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Garton, N. J. (författare)
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Barer, M. R. (författare)
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Minnikin, D. E. (författare)
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Bhatt, A. (författare)
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Besra, G. S. (författare)
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(creator_code:org_t)
- 2017-05-02
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The evolution of tubercle bacilli parallels a route from environmental Mycobacterium kansasii, through intermediate "Mycobacterium canettii", to the modern Mycobacterium tuberculosis complex. Cell envelope outer membrane lipids change systematically from hydrophilic lipooligosaccharides and phenolic glycolipids to hydrophobic phthiocerol dimycocerosates, di-and pentaacyl trehaloses and sulfoglycolipids. Such lipid changes point to a hydrophobic phenotype for M. tuberculosis sensu stricto. Using Congo Red staining and hexadecane-aqueous buffer partitioning, the hydrophobicity of rough morphology M. tuberculosis and Mycobacterium bovis strains was greater than smooth "M. canettii" and M. kansasii. Killed mycobacteria maintained differential hydrophobicity but defatted cells were similar, indicating that outer membrane lipids govern overall hydrophobicity. A rough M. tuberculosis H37Rv Delta papA1 sulfoglycolipid-deficient mutant had significantly diminished Congo Red uptake though hexadecane-aqueous buffer partitioning was similar to H37Rv. An M. kansasii, Delta MKAN27435 partially lipooligosaccharide-deficient mutant absorbed marginally more Congo Red dye than the parent strain but was comparable in partition experiments. In evolving from ancestral mycobacteria, related to "M. canettii" and M. kansasii, modern M. tuberculosis probably became more hydrophobic by increasing the proportion of less polar lipids in the outer membrane. Importantly, such a change would enhance the capability for aerosol transmission, affecting virulence and pathogenicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- mycobacterium-tuberculosis
- cell-wall
- nontuberculous mycobacteria
- colony morphology
- tubercle-bacilli
- mycolic acids
- abscessus
- rough
- complex
- smooth
- Science & Technology - Other Topics
- nnikin de
- 1990
- fems microbiology letters
- v67
- p55
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jankute, M.
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Nataraj, V.
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Lee, O. Y. C.
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Wu, H. H. T.
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Ridell, Malin, 1 ...
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Garton, N. J.
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visa fler...
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Barer, M. R.
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Minnikin, D. E.
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Bhatt, A.
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Besra, G. S.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Göteborgs universitet