Search: id:"swepub:oai:gup.ub.gu.se/258224" >
Identification of a...
Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion
-
Romania, P. (author)
-
Cifaldi, L. (author)
-
Pignoloni, B. (author)
-
show more...
-
Starc, N. (author)
-
D'Alicandro, V. (author)
-
Melaiu, O. (author)
-
Pira, G. L. (author)
-
Giorda, E. (author)
-
Carrozzo, R. (author)
-
Bergvall, M. (author)
-
- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
- Alfredsson, L. (author)
- Karolinska Institutet
-
- Olsson, T. (author)
- Karolinska Institutet
-
- Kockum, I. (author)
- Karolinska Institutet
-
Seppala, I. (author)
-
Lehtimaki, T. (author)
-
Hurme, M. A. (author)
-
Hengel, H. (author)
-
Santoni, A. (author)
-
Cerboni, C. (author)
-
Locatelli, F. (author)
-
- D'Amato, M. (author)
- Karolinska Institutet
-
Fruci, D. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
-
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 20:4, s. 846-853
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 30 UTR, preserves ERAP1 from miR-UL1125p-mediated degradation. Specifically, HCMV miRUL112-5p binds the 30 UTR of ERAP1 A variant, but not the 30 UTR of ERAP1 G variant, and, accordingly, ERAP1 expression is reduced both at RNA and protein levels only in human fibroblasts homozygous for the A variant. Consistently, HCMV-infected GG fibroblasts were more efficient in trimming viral antigens and being lysed by HCMV-peptide-specific CTLs. Notably, a significantly decreased HCMV seropositivity was detected among GG individuals suffering from multiple sclerosis, a disease model in which HCMV is negatively associated with adultonset disorder. Overall, our results identify a resistance mechanism to HCMV miR-UL112-5p-based immune evasion strategy with potential implications for individual susceptibility to infection and other diseases.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- MULTIPLE-SCLEROSIS
- ENDOPLASMIC-RETICULUM
- INFECTION
- EXPRESSION
- MICRORNAS
- MOLECULES
- IMMUNITY
- CELLS
- RISK
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Romania, P.
-
Cifaldi, L.
-
Pignoloni, B.
-
Starc, N.
-
D'Alicandro, V.
-
Melaiu, O.
-
show more...
-
Pira, G. L.
-
Giorda, E.
-
Carrozzo, R.
-
Bergvall, M.
-
Bergström, Tomas ...
-
Alfredsson, L.
-
Olsson, T.
-
Kockum, I.
-
Seppala, I.
-
Lehtimaki, T.
-
Hurme, M. A.
-
Hengel, H.
-
Santoni, A.
-
Cerboni, C.
-
Locatelli, F.
-
D'Amato, M.
-
Fruci, D.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Cell Reports
- By the university
-
University of Gothenburg
-
Karolinska Institutet