A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model

Hedenqvist, Patricia (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Ley, Cecilia (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health

Jensen Waern, Marianne (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Ekman, Stina (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health

Johansson, Carina B., 1955 (author): Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2

Thor, Andreas (author): Uppsala universitet,Käkkirurgi,Oral & Maxillofacial Surgery

(creator_code:org_t)

Elsevier BV, 2018
2018
English.
In: Journal of Dentistry. - : Elsevier BV. - 0300-5712 .- 1879-176X. ; 70, s. 31-39

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; https://res.slu.se/i...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Objectives The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid–calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model. Material and methods Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralateral side. In a sinus lift, the sinus mucosa was elevated and a titanium mini-implant was placed in the alveolar bone. Augmentation material (CPC, HABP·CaP or bovine bone) was applied in the space around the implant. The rabbits were euthanized three months after surgery and qualitative and histomorphometric evaluation were conducted. Histomorphometric evaluation included three different regions of interest (ROIs) and the bone to implant contact on each installed implant. Results Qualitative assessment (p=<.05), histomorphometric evaluations (p=<.01), and implant incorporation (p=<.05) showed that CPC and bovine mineral induced similar amount of bone and more than the HABP·CaP hydrogel. Conclusion CPC induced similar amount of bone as bovine mineral and both materials induced more bone than HABP·CaP hydrogel. Clinical significance The CPC is suggested as a synthetic alternative for augmentations in the maxillofacial area.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

By the author/editor: Trbakovic, Amela; Hedenqvist, Patr ...; Mellgren, Torbjö ...; Ley, Cecilia; Jensen Waern, Ma ...; Hilborn, Jöns, 1 ...; show more...; Ossipov, Dmitri ...; Ekman, Stina; Johansson, Carin ...; Thor, Andreas; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

By the university: University of Gothenburg; Swedish University of Agricultural Sciences; Uppsala University

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