Search: id:"swepub:oai:gup.ub.gu.se/264401" > TCSBN: a database o...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05503naa a2200745 4500 | |
001 | oai:gup.ub.gu.se/264401 | |
003 | SwePub | |
008 | 240528s2018 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:90ed90c9-d87e-4e7c-a1d4-ae18710515ae | |
009 | oai:DiVA.org:kth-248672 | |
024 | 7 | a https://gup.ub.gu.se/publication/2644012 URI |
024 | 7 | a https://doi.org/10.1093/nar/gkx9942 DOI |
024 | 7 | a https://research.chalmers.se/publication/5003362 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2486722 URI |
040 | a (SwePub)gud (SwePub)cthd (SwePub)kth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lee, Sunjaeu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u15y67rb |
245 | 1 0 | a TCSBN: a database of tissue and cancer specific biological networks |
264 | c 2017-10-24 | |
264 | 1 | b Oxford University Press (OUP),c 2018 |
500 | a QC 20190423 | |
520 | a Biological networks provide new opportunities for understanding the cellular biology in both health and disease states. We generated tissue specific integrated networks (INs) for liver, muscle and adipose tissues by integratingmetabolic, regulatory and protein-protein interaction networks. We also generated human co-expression networks (CNs) for 46 normal tissues and 17 cancers to explore the functional relationships between genes as well as their relationships with biological functions, and investigate the overlap between functional and physical interactions provided by CNs and INs, respectively. These networks can be employed in the analysis of omics data, provide detailed insight into disease mechanisms by identifying the key biological components and eventually can be used in the development of efficient treatment strategies. Moreover, comparative analysis of the networks may allow for the identification of tissue-specific targets that can be used in the development of drugs with the minimum toxic effect to other human tissues. These context-specific INs and CNs are presented in an interactive website http://inetmodels.com without any limitation. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
653 | a plasma mannose levels | |
653 | a fatty-acid synthase | |
653 | a systems biology | |
653 | a cardiovascular-disease | |
653 | a metabolism | |
653 | a genome | |
653 | a medicine | |
653 | a identification | |
653 | a pathogenesis | |
653 | a hallmarks | |
653 | a Biochemistry & Molecular Biology | |
700 | 1 | a Zhang, C.u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ww5kvp |
700 | 1 | a Arif, Muhammadu KTH,Systembiologi4 aut0 (Swepub:kth)u1vvaean |
700 | 1 | a Liu, Zhengtaou KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ju7n8n |
700 | 1 | a Benfeitas, Ruiu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u120u6dr |
700 | 1 | a Bidkhori, Gholamrezau KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1borjet |
700 | 1 | a Deshmukh, Sumitu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11758e9 |
700 | 1 | a Shobky, Mohamed AIu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u166mhyc |
700 | 1 | a Lovric, Alenu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1p07go9 |
700 | 1 | a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xborej |
700 | 1 | a Nielsen, Jens B,d 1962u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1avl7k2 |
700 | 1 | a Uhlén, Mathiasu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw |
700 | 1 | a Mardinoglu, Adil,d 1982u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1t8kmr6 |
710 | 2 | a KTHb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Nucleic Acids Researchd : Oxford University Press (OUP)g 46:D1q 46:D1x 0305-1048x 1362-4962 |
856 | 4 | u https://academic.oup.com/nar/article-pdf/46/D1/D595/23162947/gkx994.pdf |
856 | 4 | u https://research.chalmers.se/publication/500336/file/500336_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 | u https://kth.diva-portal.org/smash/get/diva2:1303463/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/264401 |
856 | 4 8 | u https://doi.org/10.1093/nar/gkx994 |
856 | 4 8 | u https://research.chalmers.se/publication/500336 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-248672 |
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