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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005503naa a2200745 4500
001oai:gup.ub.gu.se/264401
003SwePub
008240528s2018 | |||||||||||000 ||eng|
009oai:research.chalmers.se:90ed90c9-d87e-4e7c-a1d4-ae18710515ae
009oai:DiVA.org:kth-248672
024a https://gup.ub.gu.se/publication/2644012 URI
024a https://doi.org/10.1093/nar/gkx9942 DOI
024a https://research.chalmers.se/publication/5003362 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2486722 URI
040 a (SwePub)gud (SwePub)cthd (SwePub)kth
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Lee, Sunjaeu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u15y67rb
2451 0a TCSBN: a database of tissue and cancer specific biological networks
264 c 2017-10-24
264 1b Oxford University Press (OUP),c 2018
500 a QC 20190423
520 a Biological networks provide new opportunities for understanding the cellular biology in both health and disease states. We generated tissue specific integrated networks (INs) for liver, muscle and adipose tissues by integratingmetabolic, regulatory and protein-protein interaction networks. We also generated human co-expression networks (CNs) for 46 normal tissues and 17 cancers to explore the functional relationships between genes as well as their relationships with biological functions, and investigate the overlap between functional and physical interactions provided by CNs and INs, respectively. These networks can be employed in the analysis of omics data, provide detailed insight into disease mechanisms by identifying the key biological components and eventually can be used in the development of efficient treatment strategies. Moreover, comparative analysis of the networks may allow for the identification of tissue-specific targets that can be used in the development of drugs with the minimum toxic effect to other human tissues. These context-specific INs and CNs are presented in an interactive website http://inetmodels.com without any limitation.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe
650 7a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
653 a plasma mannose levels
653 a fatty-acid synthase
653 a systems biology
653 a cardiovascular-disease
653 a metabolism
653 a genome
653 a medicine
653 a identification
653 a pathogenesis
653 a hallmarks
653 a Biochemistry & Molecular Biology
700a Zhang, C.u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ww5kvp
700a Arif, Muhammadu KTH,Systembiologi4 aut0 (Swepub:kth)u1vvaean
700a Liu, Zhengtaou KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ju7n8n
700a Benfeitas, Ruiu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u120u6dr
700a Bidkhori, Gholamrezau KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1borjet
700a Deshmukh, Sumitu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11758e9
700a Shobky, Mohamed AIu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u166mhyc
700a Lovric, Alenu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1p07go9
700a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xborej
700a Nielsen, Jens B,d 1962u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1avl7k2
700a Uhlén, Mathiasu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw
700a Mardinoglu, Adil,d 1982u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1t8kmr6
710a KTHb Science for Life Laboratory, SciLifeLab4 org
773t Nucleic Acids Researchd : Oxford University Press (OUP)g 46:D1q 46:D1x 0305-1048x 1362-4962
856u https://academic.oup.com/nar/article-pdf/46/D1/D595/23162947/gkx994.pdf
856u https://research.chalmers.se/publication/500336/file/500336_Fulltext.pdfx primaryx freey FULLTEXT
856u https://kth.diva-portal.org/smash/get/diva2:1303463/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/264401
8564 8u https://doi.org/10.1093/nar/gkx994
8564 8u https://research.chalmers.se/publication/500336
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-248672

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