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Ongoing or previous...
Ongoing or previous mental disorders predispose to adverse mood reporting during combined oral contraceptive use
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- Bengtsdotter, H. (author)
- Department of Obstetrics and Gynaecology, Örebro University, Örebro, Sweden,Örebro Univ, Dept Obstet & Gynaecol, Örebro, Sweden.
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- Lundin, Cecilia (author)
- Uppsala universitet,Reproduktiv hälsa,Uppsala Univ, Sweden
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- Danielsson, K. G. (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Bixo, Marie (author)
- Umeå universitet,Obstetrik och gynekologi,Umea Univ, Dept Clin Sci, Umea, Sweden.
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- Baumgart, Juliane, 1978- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Obstetrics and Gynaecology,Örebro Univ, Dept Obstet & Gynaecol, Örebro, Sweden.
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- Marions, L. (author)
- Karolinska Institutet,Karolinska Inst Södersjukhuset, Sweden
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- Brynhildsen, Jan, 1962- (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Malmborg, Agota (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Lindh, Ingela, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynaecology, Sahlgrenska Academy at Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden,Gothenburg Univ, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Obstet & Gynaecol, Gothenburg, Sweden.
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Reproduktiv hälsa,Uppsala Univ, Sweden
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Department of Obstetrics and Gynaecology, Örebro University, Örebro, Sweden Örebro Univ, Dept Obstet & Gynaecol, Örebro, Sweden (creator_code:org_t)
- 2018-01-11
- 2018
- English.
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In: European Journal of Contraception and Reproductive Health Care. - : Informa UK Limited. - 1362-5187 .- 1473-0782. ; 23:1, s. 45-51
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Abstract
Subject headings
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- Purpose: Previous studies have emphasised that women with pre-existing mood disorders are more inclined to discontinue hormonal contraceptive use. However, few studies have examined the effects of combined oral contraceptives (COC) on mood in women with previous or ongoing mental disorders. Materials and methods: This is a supplementary analysis of an investigator-initiated, double-blinded, randomised clinical trial during which 202 women were treated with either a COC (1.5mg estradiol and 2.5mg nomegestrolacetate) or placebo during three treatment cycles. The Mini International Neuropsychiatric Interview was used to collect information on previous or ongoing mental disorders. The primary outcome measure was the total change score in five mood symptoms on the Daily Record of Severity of Problems (DRSP) scale in the intermenstrual phase of the treatment cycle. Results: Women with ongoing or previous mood, anxiety or eating disorders allocated to COC had higher total DRSP -scores during the intermenstrual phase of the treatment cycle in comparison with corresponding women randomised to placebo, mean difference 1.3 (95% CI 0.3-2.3). In contrast, among women without mental health problems, no difference in total DRSP -scores between COC- and placebo users was noted. Women with a risk use of alcohol who were randomised to the COC had higher total DRSP -scores than women randomised to placebo, mean difference 2.1 (CI 95% 1.0-3.2). Conclusions: Women with ongoing or previous mental disorders or risk use of alcohol have greater risk of COC-induced mood symptoms. This may be worth noting during family planning and contraceptive counselling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Randomised controlled trial
- combined oral contraceptives
- anxiety
- depression
- alcohol
- depressive symptoms
- breast-cancer
- hormonal contraception
- alcohol-consumption
- major depression
- women
- association
- mechanisms
- discontinuation
- epidemiology
- Public
- Environmental & Occupational Health
- Obstetrics & Gynecology
- Randomised controlled trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bengtsdotter, H.
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Lundin, Cecilia
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Danielsson, K. G ...
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Bixo, Marie
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Baumgart, Julian ...
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Marions, L.
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Brynhildsen, Jan ...
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Malmborg, Agota
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Lindh, Ingela, 1 ...
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Sundström Poroma ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Linköping University