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Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link

Ramos-Cejudo, J. (author)
Wisniewski, T. (author)
Marmar, C. (author)
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Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
de Leon, M. J. (author)
Fossati, S. (author)
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 (creator_code:org_t)
Elsevier BV, 2018
2018
English.
In: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 28, s. 21-30
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent amechanistic link between A beta/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid beta (A beta) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/A beta-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop. We postulate that TBI can initiate cerebrovascular pathology, which is causally involved in the development of multiple forms of neurodegeneration including AD-like dementias. In this review, we will explore hownovel biomarkers, animal and human studies with a focus on cerebrovascular dysfunction are contributing to the understanding of the consequences of TBI on the development of AD-like pathology.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Traumatic brain injury
Alzheimer's disease
Cerebrovascular pathology
Biomarkers
A beta
Tau
white-matter damage
cerebral amyloid angiopathy
endothelial
nitric-oxide
total tau
cerebrospinal-fluid
blood biomarkers
murine
model
mouse model
cognitive impairment
neurovascular unit
General & Internal Medicine
Research & Experimental Medicine

Publication and Content Type

ref (subject category)
art (subject category)

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