Search: id:"swepub:oai:gup.ub.gu.se/268274" >
Testosterone Protec...
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells.
-
- Wilhelmson, Anna S K (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
-
- Lantero Rodriguez, Marta (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
-
- Svedlund Eriksson, Elin (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberg Laboratory,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
show more...
-
- Johansson, Inger, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
-
- Fogelstrand, Per, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
-
- Stubelius, Alexandra, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
- Lindgren, Susanne, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Clinical Sciences, Department of Pediatrics
-
- Fagman, Johan Bourghardt, 1980 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberg Laboratory,Institute of Clinical Sciences, Department of Surgery
-
- Hansson, Göran K (author)
- Karolinska Institutet
-
- Carlsten, Hans, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
- Karlsson, Mikael C I (author)
- Karolinska Institutet
-
- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
- Tivesten, Åsa, 1969 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberg Laboratory,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
show less...
-
(creator_code:org_t)
- 2018
- 2018
- English.
-
In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 38:7, s. 1519-1527
- Related links:
-
https://gup.ub.gu.se... (primary) (free)
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Androgen deprivation therapy has been associated with increased cardiovascular risk in men. Experimental studies support that testosterone protects against atherosclerosis, but the target cell remains unclear. T cells are important modulators of atherosclerosis, and deficiency of testosterone or its receptor, the AR (androgen receptor), induces a prominent increase in thymus size. Here, we tested the hypothesis that atherosclerosis induced by testosterone deficiency in male mice is T-cell dependent. Further, given the important role of the thymic epithelium for T-cell homeostasis and development, we hypothesized that depletion of the AR in thymic epithelial cells will result in increased atherosclerosis.Prepubertal castration of male atherosclerosis-prone apoE-/- mice increased atherosclerotic lesion area. Depletion of T cells using an anti-CD (cluster of differentiation) 3 antibody abolished castration-induced atherogenesis, demonstrating a role of T cells. Male mice with depletion of the AR specifically in epithelial cells (E-ARKO [epithelial cell-specific AR knockout] mice) showed increased thymus weight, comparable with that of castrated mice. E-ARKO mice on an apoE-/- background displayed significantly increased atherosclerosis and increased infiltration of T cells in the vascular adventitia, supporting a T-cell-driven mechanism. Consistent with a role of the thymus, E-ARKO apoE-/- males subjected to prepubertal thymectomy showed no atherosclerosis phenotype.We show that atherogenesis induced by testosterone/AR deficiency is thymus- and T-cell dependent in male mice and that the thymic epithelial cell is a likely target cell for the antiatherogenic actions of testosterone. These insights may pave the way for new therapeutic strategies for safer endocrine treatment of prostate cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wilhelmson, Anna ...
-
Lantero Rodrigue ...
-
Svedlund Eriksso ...
-
Johansson, Inger ...
-
Fogelstrand, Per ...
-
Stubelius, Alexa ...
-
show more...
-
Lindgren, Susann ...
-
Fagman, Johan Bo ...
-
Hansson, Göran K
-
Carlsten, Hans, ...
-
Karlsson, Mikael ...
-
Ekwall, Olov, 19 ...
-
Tivesten, Åsa, 1 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Arteriosclerosis ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet