Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

Suhm, Tamara (author): Stockholms universitet,Institutionen för biokemi och biofysik

Kaimal, Jayasankar Mohanakrishnan (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut

Dawitz, Hannah (author): Stockholms universitet,Institutionen för biokemi och biofysik

Peselj, Carlotta (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut

Masser, Anna E. (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut

Hanzén, Sarah (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine

Ambrozic, M. (author): Stockholms universitet,Institutionen för biokemi och biofysik

Smialowska, Agata (author): Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)

Björck, Markus L. (author): Stockholms universitet,Institutionen för biokemi och biofysik

Brzezinski, Peter (author): Stockholms universitet,Institutionen för biokemi och biofysik

Nyström, Thomas, 1960 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine

Büttner, Sabrina (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria

Andréasson, Claes (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut

Ott, Martin (author): Stockholms universitet,Institutionen för biokemi och biofysik

(creator_code:org_t)

Related links:: http://www.cell.com/...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Cellular proteostasis ismaintained via the coordinated synthesis, maintenance, and breakdown of proteins in the cytosol and organelles. While biogenesis of the mitochondrial membrane complexes that execute oxidative phosphorylation depends on cytoplasmic translation, it is unknown how translation within mitochondria impacts cytoplasmic proteostasis and nuclear gene expression. Here we have analyzed the effects of mutations in the highly conserved accuracy center of the yeast mitoribosome. Decreased accuracy of mitochondrial translation shortened chronological lifespan, impaired management of cytosolic protein aggregates, and elicited a general transcriptional stress response. In striking contrast, increased accuracy extended lifespan, improved cytosolic aggregate clearance, and suppressed a normally stress-induced, Msn2/4-dependent interor-ganellar proteostasis transcription program (IPTP) that regulates genes important for mitochondrial proteostasis. Collectively, the data demonstrate that cytosolic protein homeostasis and nuclear stress signaling are controlled by mitochondrial translation efficiency in an inter-connected organelle quality control network that determines cellular lifespan.

NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
NATURVETENSKAP -- Biologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences (hsv//eng)

By the author/editor: Suhm, Tamara; Kaimal, Jayasank ...; Dawitz, Hannah; Peselj, Carlotta; Masser, Anna E.; Hanzén, Sarah; show more...; Ambrozic, M.; Smialowska, Agat ...; Björck, Markus L ...; Brzezinski, Pete ...; Nyström, Thomas, ...; Büttner, Sabrina; Andréasson, Clae ...; Ott, Martin; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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