Mass Spectrometry Imaging Shows Cocaine and Methylphenidate Have Opposite Effects on Major Lipids in Drosophila Brain

Philipsen, Mai H., 1988 (author): Gothenburg University,Göteborgs universitet,National Center for Imaging Mass Spectrometry,Chalmers tekniska högskola,Chalmers University of Technology

Phan, Nhu TN, 1981 (author): Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,National Center for Imaging Mass Spectrometry,Department of Chemistry and Molecular Biology,Universitätsmedizin Göttingen,University Medical Center Göttingen,University of Gothenburg

Fletcher, John S. (author): Gothenburg University,Göteborgs universitet,National Center for Imaging Mass Spectrometry,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg

Malmberg, Per, 1974 (author): Gothenburg University,Göteborgs universitet,National Center for Imaging Mass Spectrometry,Chalmers tekniska högskola,Chalmers University of Technology

Ewing, Andrew G, 1957 (author): Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,National Center for Imaging Mass Spectrometry,Department of Chemistry and Molecular Biology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology

(creator_code:org_t)

2018-03-06
2018
English.
In: Acs Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 9:6, s. 1462-1468

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Abstract Subject headings

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was used to study the effects of cocaine versus methylphenidate administration on both the localization and abundance of lipids in Drosophila melanogaster brain. A J105 ToF-SIMS with a 40 keV gas cluster primary ion source enabled us to probe molecular ions of biomolecules on the fly with a spatial resolution of similar to 3 mu m, giving us unique insights into the effect of these drugs on molecular lipids in the nervous system. Significant changes in phospholipid composition were observed in the central brain for both. Principal components image analysis revealed that changes occurred mainly for phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols. When the lipid changes caused by cocaine were compared with those induced by methylphenidate, it was shown that these drugs exert opposite effects on the brain lipid structure. We speculate that this might relate to the molecular mechanism of cognition and memory.

NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)

By the author/editor: Philipsen, Mai H ...; Phan, Nhu TN, 19 ...; Fletcher, John S ...; Malmberg, Per, 1 ...; Ewing, Andrew G, ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Atom and Molecul ...

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Other Chemistry ...

By the university: University of Gothenburg; Chalmers University of Technology

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