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Spatiotemporal segr...
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue.
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Zhao, Yuan (author)
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Uduman, Mohamed (author)
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Siu, Jacqueline H Y (author)
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Tull, Thomas J (author)
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Sanderson, Jeremy D (author)
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Wu, Yu-Chang Bryan (author)
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Zhou, Julian Q (author)
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Petrov, Nedyalko (author)
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Ellis, Richard (author)
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Todd, Katrina (author)
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Chavele, Konstantia-Maria (author)
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Guesdon, William (author)
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Vossenkamper, Anna (author)
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Jassem, Wayel (author)
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D'Cruz, David P (author)
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Fear, David J (author)
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John, Susan (author)
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Scheel-Toellner, Dagmar (author)
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Hopkins, Claire (author)
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Moreno, Estefania (author)
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Woodman, Natalie L (author)
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Ciccarelli, Francesca (author)
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Heck, Susanne (author)
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Kleinstein, Steven H (author)
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- Bemark, Mats, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Spencer, Jo (author)
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(creator_code:org_t)
- 2018-09-21
- 2018
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the relationship between them is controversial. Here, we show phenotypic progression within lymphoid tissues as MZ B cells emerge from the mature naïve B cell pool via a precursor CD27-CD45RBMEM55+ population distant from memory cells. By imaging mass cytometry, we find that MZ B cells and memory B cells occupy different microanatomical niches in organised gut lymphoid tissues. Both populations disseminate widely between distant lymphoid tissues and blood, and both diversify their IGHV repertoire in gut germinal centres (GC), but nevertheless remain largely clonally separate. MZ B cells are therefore not developmentally contiguous with or analogous to classical memory B cells despite their shared ability to transit through GC, where somatic mutations are acquired.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhao, Yuan
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Uduman, Mohamed
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Siu, Jacqueline ...
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Tull, Thomas J
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Sanderson, Jerem ...
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Wu, Yu-Chang Bry ...
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show more...
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Zhou, Julian Q
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Petrov, Nedyalko
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Ellis, Richard
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Todd, Katrina
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Chavele, Konstan ...
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Guesdon, William
-
Vossenkamper, An ...
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Jassem, Wayel
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D'Cruz, David P
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Fear, David J
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John, Susan
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Scheel-Toellner, ...
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Hopkins, Claire
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Moreno, Estefani ...
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Woodman, Natalie ...
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Ciccarelli, Fran ...
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Heck, Susanne
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Kleinstein, Stev ...
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Bemark, Mats, 19 ...
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Spencer, Jo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Nature communica ...
- By the university
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University of Gothenburg