Sökning: id:"swepub:oai:gup.ub.gu.se/271572" > Vascular endothelia...
Fältnamn | Indikatorer | Metadata |
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000 | 04246naa a2200709 4500 | |
001 | oai:gup.ub.gu.se/271572 | |
003 | SwePub | |
008 | 240528s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2715722 URI |
024 | 7 | a https://doi.org/10.1016/j.jpedsurg.2009.10.0022 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Burgu, Berk4 aut |
245 | 1 0 | a Vascular endothelial growth factor and bladder from a different perspective: not only an angiogenic factor. |
264 | 1 | b Elsevier BV,c 2010 |
520 | a Angiogenesis has a key role for embryonic development and is crucial in several major diseases. Molecular basis of angiogenesis has been widely investigated (J Biochem Mol Biol. 2006;39:469-478, Oncogene. 2000;19:5598-5605). In this review, vascular endothelial growth factor (VEGF) and related receptors and their key roles in embryonic bladder development are discussed. The normal VEGF expression and related angiogenesis pattern of embryonic bladder are highlighted. The VEGF family especially VEGF-A is the major player in angiogenesis as well as many other angiogenic factors and activates 2 tyrosine kinase receptors, VEGFR-1 and VEGFR-2 (J Biochem Mol Biol. 2006;39:469-478). Besides its worthy role in angiogenesis, VEGF-A also seems to participate in normal bladder development (J Urol. 2007;177:1552-1557, Br J Urol Int. 2006;98:217-225). In previous studies, we have shown that exogenous VEGF or hypoxia-induced endogenous upregulation of this protein accelerates the growth of the bladder by detrusor and urothelium hypertrophy and hyperplasia (J Urol. 2007;177:1552-1557, Br J Urol Int. 2006;98:217-225, Dev Biol. 1997;183:139-149, Neurourol Urodyn. 2004;23:342-348). This abrupt role of VEGF on detrusor muscle through a hypoxic pathway may potentially be a part of the solution for many urologic conditions such as remodeling of detrusor muscle in antenatal bladder outlet obstruction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
653 | a Angiogenesis Inducing Agents | |
653 | a pharmacology | |
653 | a Animals | |
653 | a Embryonic Development | |
653 | a genetics | |
653 | a physiology | |
653 | a Female | |
653 | a Humans | |
653 | a Mice | |
653 | a Organogenesis | |
653 | a genetics | |
653 | a physiology | |
653 | a Pregnancy | |
653 | a Urinary Bladder | |
653 | a embryology | |
653 | a Urinary Bladder Neck Obstruction | |
653 | a genetics | |
653 | a physiopathology | |
653 | a Vascular Endothelial Growth Factor A | |
653 | a genetics | |
653 | a physiology | |
653 | a Vascular Endothelial Growth Factor Receptor-1 | |
653 | a drug effects | |
653 | a genetics | |
653 | a physiology | |
653 | a Vascular Endothelial Growth Factor Receptor-2 | |
653 | a drug effects | |
653 | a genetics | |
653 | a physiology | |
653 | a Vascular Endothelial Growth Factors | |
653 | a genetics | |
653 | a physiology | |
700 | 1 | a Aydogdu, Özgu,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xaydzg |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi4 org |
773 | 0 | t Journal of pediatric surgeryd : Elsevier BVg 45:2, s. 447-52q 45:2<447-52x 1531-5037x 0022-3468 |
856 | 4 8 | u https://gup.ub.gu.se/publication/271572 |
856 | 4 8 | u https://doi.org/10.1016/j.jpedsurg.2009.10.002 |
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