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Advances in therape...
Advances in therapeutic applications of extracellular vesicles
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- Wiklander, O. P. B. (författare)
- Karolinska Institutet
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Brennan, M. A. (författare)
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- Lötvall, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Breakefield, X. O. (författare)
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- El Andaloussi, S. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2019
- 2019
- Engelska.
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 11:492
- Relaterad länk:
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- mesenchymal stromal cells
- exosome-mediated delivery
- dendritic cells
- drug-delivery
- gene delivery
- in-vitro
- neutralizing antibodies
- transferrin receptor
- membrane-vesicles
- immune-responses
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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