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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04521naa a2200517 4500 | |
| 001 | oai:gup.ub.gu.se/283698 | |
| 003 | SwePub | |
| 008 | 240910s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141653268 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2836982 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-019-48795-w2 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1416532682 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Karlsson, Lars O,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xkarlq |
| 245 | 1 0 | a Constitutive PGC-1 alpha overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis |
| 264 | c 2019-08-23 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1 alpha) mediates many of the exercise-induced benefits in skeletal muscle, including the release of factors into the circulation with neurotrophic effects. We use a transgenic mouse model with muscle-specific overexpression of PGC-1 alpha to study the contribution of chronic muscle activation on exercise-induced effects on hippocampal neurogenesis in aging. Young and old transgenic and wild type animals of both sexes displayed a robust age-related reduction in newborn BrdU+-cells, immature neurons (DCX+-cells) and new mature BrdU(+)/NeuN(+)-neurons in the dentate gyrus. No differences were detected between genotypes or sexes. Analysis of serum proteins showed a tendency towards increased levels of myokines and reduced levels of pro-inflammatory cytokines for transgenic animals, but only musclin was found to be significantly up-regulated in transgenic animals. We conclude that constitutive muscular overexpression of PGC-1 alpha, despite potent systemic changes, is insufficient for mimicking exercise-induced effects on hippocampal neurogenesis in aging. Continued studies are required to investigate the complex molecular mechanisms by which circulating signals could mediate exercise-induced effects on the central nervous system in disease and aging, with the aim of discovering new therapeutic possibilities for patients. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a adult hippocampal neurogenesis | |
| 653 | a dentate gyrus | |
| 653 | a mitochondrial biogenesis | |
| 653 | a neuromuscular-junction | |
| 653 | a physical-exercise | |
| 653 | a sex-differences | |
| 653 | a messenger-rna | |
| 653 | a estradiol | |
| 653 | a memory | |
| 653 | a vegf | |
| 653 | a Science & Technology - Other Topics | |
| 700 | 1 | a González-Alvarado, María Nazarethu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut |
| 700 | 1 | a Motalleb, Reza,d 1985u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xmotre |
| 700 | 1 | a Blomgren, K.u Karolinska Institutet4 aut |
| 700 | 1 | a Börjesson, Mats,d 1965u Gothenburg University,Göteborgs universitet,Centrum för hälsa och prestationsutveckling,Institutionen för neurovetenskap och fysiologi,Center for Health and Performance,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xborjm |
| 700 | 1 | a Kuhn, Hans-Georg,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xkuhha |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 9q 9x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-019-48795-w.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/283698 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-019-48795-w |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141653268 |
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