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Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
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- Johansson, Viktoria (author)
- Karolinska Institutet
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- Erhardt, S. (author)
- Karolinska Institutet
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- Engberg, G. (author)
- Karolinska Institutet
- show more...
- Kegel, M. (author)
- Bhat, M. (author)
- Cannon, T. D. (author)
- Hultman, C. M. (author)
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- (creator_code:org_t)
- 2019-07-13
- 2020
- English.
- In: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 270:7, s. 933-938
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. © 2019, The Author(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Biomarker
- Cerebrospinal fluid
- Chemokine ligand 2
- Kynurenic acid
- Monocyte chemoattractant protein-1
- Twin study
- Biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Blennow, Kaj, 19 ...
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- Cannon, T. D.
- Wetterberg, L.
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