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Twin study shows as...
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
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- Johansson, Viktoria (author)
- Karolinska Institutet
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- Erhardt, S. (author)
- Karolinska Institutet
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- Engberg, G. (author)
- Karolinska Institutet
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Kegel, M. (author)
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Bhat, M. (author)
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- Schwieler, L. (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Cannon, T. D. (author)
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- Wetterberg, L. (author)
- Karolinska Institutet
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Hultman, C. M. (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2019-07-13
- 2020
- English.
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In: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 270:7, s. 933-938
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Abstract
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- Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. © 2019, The Author(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Biomarker
- Cerebrospinal fluid
- Chemokine ligand 2
- Kynurenic acid
- Monocyte chemoattractant protein-1
- Twin study
- Biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Vikto ...
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Erhardt, S.
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Engberg, G.
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Kegel, M.
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Bhat, M.
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Schwieler, L.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Cannon, T. D.
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Wetterberg, L.
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Hultman, C. M.
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Landén, Mikael, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Archive ...
- By the university
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University of Gothenburg
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Umeå University
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Karolinska Institutet