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Brain and blood bio...
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure
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Dickstein, D. L. (author)
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De Gasperi, R. (author)
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Sosa, M. G. A. (author)
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Perez-Garcia, G. (author)
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Short, J. A. (author)
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Sosa, H. (author)
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Perez, G. M. (author)
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Tschiffely, A. E. (author)
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Dams-O'Connor, K. (author)
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Pullman, M. Y. (author)
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Knesaurek, K. (author)
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Knutsen, A. (author)
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Pham, D. L. (author)
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Soleimani, L. (author)
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Jordan, B. D. (author)
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Gordon, W. A. (author)
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Delman, B. N. (author)
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Shumyatsky, G. (author)
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Shahim, P. P. (author)
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DeKosky, S. T. (author)
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Stone, J. R. (author)
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Peskind, E. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Chance, S. A. (author)
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Torso, M. (author)
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Kostakoglu, L. (author)
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Sano, M. (author)
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Hof, P. R. (author)
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Ahlers, S. T. (author)
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Gandy, S. (author)
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Elder, G. A. (author)
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(creator_code:org_t)
- 2020-02-25
- 2021
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 5940-5954
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [F-18]AV1451 (flortaucipir) tau ligand, we found that five of 10 veterans exhibited excessive retention of [F-18]AV1451 at the white/gray matter junction in frontal, parietal, and temporal brain regions, a typical localization of CTE tauopathy. We also observed elevated levels of neurofilament light (NfL) chain protein in the plasma of veterans displaying excess [F-18]AV1451 retention. These findings suggest an association linking blast injury, tauopathy, and neuronal injury. Further study is required to determine whether clinical, neuroimaging, and/or fluid biomarker signatures can improve the diagnosis of long-term neuropsychiatric sequelae of mTBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- persistent postconcussive symptoms
- military service members
- pet tracer
- f-18-av-1451
- disorder-related traits
- cognitive impairment
- tau
- model
- expression
- dementia
- disease
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Dickstein, D. L.
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De Gasperi, R.
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Sosa, M. G. A.
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Perez-Garcia, G.
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Short, J. A.
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Sosa, H.
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show more...
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Perez, G. M.
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Tschiffely, A. E ...
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Dams-O'Connor, K ...
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Pullman, M. Y.
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Knesaurek, K.
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Knutsen, A.
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Pham, D. L.
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Soleimani, L.
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Jordan, B. D.
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Gordon, W. A.
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Delman, B. N.
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Shumyatsky, G.
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Shahim, P. P.
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DeKosky, S. T.
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Stone, J. R.
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Peskind, E.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Chance, S. A.
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Torso, M.
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Kostakoglu, L.
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Sano, M.
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Hof, P. R.
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Ahlers, S. T.
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Gandy, S.
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Elder, G. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg