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Oxytocin Receptors ...
Oxytocin Receptors Regulate Social Preference in Zebrafish.
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- Landin, Jenny (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Pharmacol, Gothenburg, Sweden.
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- Hovey, Daniel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Pharmacol, Gothenburg, Sweden.
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- Xu, Bo, 1980- (author)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab
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- Lagman, David, 1987- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för neurovetenskap
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- Zettergren, Anna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden.
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- Larhammar, Dan, 1956- (author)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab
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- Kettunen, Petronella (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden.
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Pharmacol, Gothenburg, Sweden.
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(creator_code:org_t)
- 2020-03-25
- 2020
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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https://doi.org/10.1...
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Abstract
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- With a strong tendency to socialise, the zebrafish is a useful model to study social behaviour, with implications for better treatments of social impairments, for instance in autism spectrum disorders. Although oxytocin is crucial for social behaviour in mammals, the importance of the fish orthologue - isotocin or zebrafish oxytocin (zOT) - for social behaviour in zebrafish is unclear. The aims of this study were firstly, to elucidate the receptor specificity of zOT and the related vasotocin or zebrafish vasopressin (zVP; the orthologue of mammalian vasopressin) and the nonpeptidergic oxytocin receptor antagonist L-368,899, and secondly to investigate if L-368,899 inhibits social preference in zebrafish. The potencies of ligands were evaluated for zOT/zVP family receptors in HEK293 cells. Adult and larval zebrafish were treated with L-368,899 or vehicle and subsequently assessed for social behaviour and anxiety (adults only). The antagonist L-368,899 specifically inhibited the two zOT receptors, but not the two zVP-1 receptors. The antagonist decreased social preference in adult and larval zebrafish. It did not affect anxiety in adults. These results indicate that endogenous zOT, and possibly zVP, is involved in social behaviour in zebrafish via either or both of the two zOT receptors, and show promise for future explorations of the anatomy and evolution of networks underlying social behaviour.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Landin, Jenny
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Hovey, Daniel
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Xu, Bo, 1980-
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Lagman, David, 1 ...
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Zettergren, Anna ...
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Larhammar, Dan, ...
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show more...
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Kettunen, Petron ...
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Westberg, Lars, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Scientific repor ...
- By the university
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University of Gothenburg
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Uppsala University