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A new type of MAML2 fusion in mucoepidermoid carcinoma.
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- Fehr, Andre (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine,Institute of Biomedicine, Department of Pathology
- Röser, K. (author)
- Heidorn, K. (author)
- show more...
- Hallas, C. (author)
- Löning, T. (author)
- Bullerdiek, J. (author)
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- (creator_code:org_t)
- 2008
- 2008
- English.
- In: Genes, chromosomes & cancer. - : Wiley. - 1098-2264 .- 1045-2257. ; 47:3, s. 203-6
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The present study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these samples, a CRTC3-MAML2 fusion gene was detected. Thus, this report demonstrates the existence of a fusion of MAML2 with CREB regulated transcriptional coactivator CRTC3 additional to the already known fusion of MAML2 and CRTC1. Both gene fusions seem to result in an identical tumor phenotype and the fusion genes CRTC1-MAML2 and CRTC3-MAML2 may play a similar role in the development of mucoepidermoid carcinomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Carcinoma
- Mucoepidermoid
- genetics
- pathology
- DNA-Binding Proteins
- genetics
- Humans
- Nuclear Proteins
- genetics
- Oncogene Proteins
- Fusion
- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Alignment
- Sequence Analysis
- DNA
- Transcription Factors
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Fehr, Andre
- Röser, K.
- Heidorn, K.
- Hallas, C.
- Löning, T.
- Bullerdiek, J.
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- MEDICAL AND HEALTH SCIENCES
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- University of Gothenburg
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