Sökning: id:"swepub:oai:gup.ub.gu.se/294615" >
Ultrasensitive and ...
Ultrasensitive and Selective Copper(II) Detection: Introducing a Bioinspired and Robust Sensor
-
Muller, L. K. (författare)
-
Duznovic, I. (författare)
-
- Tietze, Daniel, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
visa fler...
-
Weber, W. (författare)
-
Ali, M. (författare)
-
Stein, V. (författare)
-
Ensinger, W. (författare)
-
- Tietze, Alesia A., 1984 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
visa färre...
-
(creator_code:org_t)
- 2020-06-17
- 2020
- Engelska.
-
Ingår i: Chemistry-a European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 26:39, s. 8511-8517
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- A nanopore-based Cu-II-sensing system is reported that allows for an ultrasensitive and selective detection of Cu(II)with the possibility for a broad range of applications, for example in medical diagnostics. A fluorescent ATCUN-like peptide 5/6-FAM-Dap-beta-Ala-His is employed to selectively bind Cu(II)ions in the presence of Ni(II)and Zn(II)and was crafted into ion track-etched nanopores. Upon Cu(II)binding the fluorescence of the peptide sensor is quenched, permitting the detection of Cu(II)in solution. The ion transport characteristics of peptide-modified nanopore are shown to be extremely sensitive and selective towards Cu(II)allowing to sense femtomolar Cu(II)concentrations in human urine mimics. Washing with EDTA fully restores the Cu-II-binding properties of the sensor, enabling multiple repetitive measurements. The robustness of the system clearly has the potential to be further developed into an easy-to-use, lab-on-chip Cu-II-sensing device, which will be of great importance for bedside diagnosis and monitor of Cu(II)levels in patients with copper-dysfunctional homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- ATCUN
- copper
- fluorescence
- nanopores
- sensors
- metal-binding
- alzheimers-disease
- nanopore sensor
- atcun motif
- cu(ii)
- serum
- ions
- peptides
- design
- Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas