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Hepatic saturated f...
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
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Roumans, K. H. M. (author)
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Lindeboom, L. (author)
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Veeraiah, P. (author)
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Remie, C. M. E. (author)
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Phielix, E. (author)
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Havekes, B. (author)
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Bruls, Y. M. H. (author)
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Brouwers, Mcgj (author)
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- Ståhlman, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Alssema, M. (author)
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Peters, H. P. F. (author)
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de Mutsert, R. (author)
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Staels, B. (author)
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Taskinen, M. R. (author)
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Schrauwen, P. (author)
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Schrauwen-Hinderling, V. B. (author)
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(creator_code:org_t)
- 2020-04-20
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (H-1-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our H-1-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity. Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use H-1-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Roumans, K. H. M ...
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Lindeboom, L.
-
Veeraiah, P.
-
Remie, C. M. E.
-
Phielix, E.
-
Havekes, B.
-
show more...
-
Bruls, Y. M. H.
-
Brouwers, Mcgj
-
Ståhlman, Marcus ...
-
Alssema, M.
-
Peters, H. P. F.
-
de Mutsert, R.
-
Staels, B.
-
Taskinen, M. R.
-
Borén, Jan, 1963
-
Schrauwen, P.
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Schrauwen-Hinder ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg