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The effect of vitam...
The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: a systematic review and meta-analysis of randomized controlled trials
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Li, B. B. (författare)
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Xu, Y. R. (författare)
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Zhang, X. L. (författare)
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Zhang, L. L. (författare)
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Wu, Y. A. (författare)
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- Wang, X. Y. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Zhu, Changlian, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
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(creator_code:org_t)
- 2020-09-07
- 2022
- Engelska.
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Ingår i: Nutritional Neuroscience. - : Informa UK Limited. - 1028-415X .- 1476-8305. ; 25:4, s. 835-845
- Relaterad länk:
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https://www.tandfonl...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective:The effect of vitamin D supplementation on the risk of Autism Spectrum Disorder (ASD) is conflicting. The aim of this study was to estimate the efficacy of vitamin D supplementation on ASD in children. Methods:We conducted a meta-analysis of randomized controlled trials (RCTs) in which vitamin D supplementation was used as a therapy in children with ASD. The PubMed, PsychINFO, Cochrane CENTRAL library, Web of Science, and Cinahl databases were searched from inception to March 20, 2019, for all publications on vitamin D and ASD with no restrictions. Studies involving individuals aged <18 years diagnosed with ASD and with all functional outcomes assessed by measurement scales for ASD were included. Mean differences were pooled, and a meta-analysis was performed using a random-effects model due to differences between the individual RCTs. Results:There were five RCTs with 349 children with ASD in the review, of which three RCTs were included in the meta-analysis. Vitamin D supplementation indicated a small but significant improvement in hyperactivity scores (pooled MD: -3.20; 95% CI: [-6.06, -0.34]) with low heterogeneity (I-2 = 10%,p = 0.33), but there were no other statistically significant differences in ASD symptoms between groups as measured by validated scales. Conclusion:Vitamin D supplementation appears to be beneficial for hyperactivity but not for core symptoms or other co-existing behaviors and conditions of ASD. Future RCTs with large sample sizes examining the effect of vitamin D supplementation on ASD among individuals with low serum vitamin D levels at baseline are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Vitamin D supplementation
- autism spectrum disorders
- children
- randomized controlled trials
- meta-analysis
- systematic review
- hyperactivity
- docosahexaenoic acid
- core symptoms
- environmental-factors
- 25-hydroxyvitamin d
- tolerability
- efficacy
- Neurosciences & Neurology
- Nutrition & Dietetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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