Search: id:"swepub:oai:gup.ub.gu.se/298309" >
Cellular expression...
Cellular expression of DNA damage/repair and reactive oxygen/nitrogen species in human periodontitis and peri-implantitis lesions
-
- Dionigi, Carlotta (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
-
- Larsson, Lena, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
-
- Carcuac, Olivier, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
-
show more...
-
- Berglundh, Tord, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
-
show less...
-
(creator_code:org_t)
- 2020-11-09
- 2020
- English.
-
In: Journal of Clinical Periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 47:12, s. 1466-1475
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Aim of the study To evaluate differences in the cellular expression of DNA damage/repair and reactive oxygen/nitrogen species between human periodontitis and peri-implantitis lesions. Material and methods 40 patients presenting with generalized severe periodontitis and 40 patients with severe peri-implantitis were included. Soft tissue biopsies were collected from diseased sites in conjunction with surgical therapy and prepared for histological analysis. Four regions of interest were identified: the pocket epithelium (PE), the infiltrated connective tissue (ICT), which was divided into one inner area facing the PE (ICT-1) and one outer area (ICT-2). A non-infiltrated connective tissue area (NCT) lateral of the ICT was also selected. Results It was demonstrated that the ICT of peri-implantitis specimens was considerably larger and contained significantly larger area proportions and densities of CD68-, MPO- and iNOS-positive cells than that of periodontitis samples. Cellular densities were overall higher in the inner ICT zone lateral of the PE (ICT-1) than in the outer ICT compartment (ICT-2). While the NCT area lateral of the ICT comprised significantly larger proportions and densities of y-H2AX-, iNOS-, NOX2-, MPO- and PAD4/MPO-positive cells in peri-implantitis than in periodontitis sites, a reverse difference was noted for the area proportion and density of 8-OHdG-positive cells in the PE. Conclusions It is suggested that peri-implantitis lesions are associated with an enhanced and upregulated host response and contain larger numbers of neutrophils, macrophages and iNOS-positive cells than periodontitis lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- biopsy
- cell density
- histology
- immunohistochemistry
- inflammation
- peri‐
- implant disease
- periodontal disease
- 2017 world workshop
- immunohistochemical characteristics
- consensus
- report
- classification
- diseases
- tissues
- pattern
- Dentistry
- Oral Surgery & Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database