Clusters of sleep apnoea phenotypes: A large pan-European study from the European Sleep Apnoea Database (ESADA)

Bailly, S. (author)

Grote, L. (author)

Hedner, Jan A, 1953 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine

Schiza, S. (author)

McNicholas, W. T. (author)

Basoglu, O. K. (author)

Lombardi, C. (author)

Dogas, Z. (author)

Roisman, G. (author)

Pataka, A. (author)

Bonsignore, M. R. (author)

Pepin, J. L. (author)

(creator_code:org_t)

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Background and objective: To personalize OSA management, several studies have attempted to better capture disease heterogeneity by clustering methods. The aim of this study was to conduct a cluster analysis of 23 000 OSA patients at diagnosis using the multinational ESADA. Methods: Data from 34 centres contributing to ESADA were used. An LCA was applied to identify OSA phenotypes in this European population representing broad geographical variations. Many variables, including symptoms, comorbidities and polysomnographic data, were included. Prescribed medications were classified according to the ATC classification and this information was used for comorbidity confirmation. Results: Eight clusters were identified. Four clusters were gender-based corresponding to 54% of patients, with two clusters consisting only of men and two clusters only of women. The remaining four clusters were mainly men with various combinations of age range, BMI, AHI and comorbidities. The preferred type of OSA treatment (PAP or mandibular advancement) varied between clusters. Conclusion: Eight distinct clinical OSA phenotypes were identified in a large pan-European database highlighting the importance of gender-based phenotypes and the impact of these subtypes on treatment prescription. The impact of cluster on long-term treatment adherence and prognosis remains to be studied using the ESADA follow-up data set. © 2020 Asian Pacific Society of Respirology

By the author/editor: Bailly, S.; Grote, L.; Hedner, Jan A, 1 ...; Schiza, S.; McNicholas, W. T ...; Basoglu, O. K.; show more...; Lombardi, C.; Dogas, Z.; Roisman, G.; Pataka, A.; Bonsignore, M. R ...; Pepin, J. L.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.