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In vitro and in viv...
In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels
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- Håkansson, Joakim, 1975 (author)
- RISE,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Kemi, biomaterial och textil,Gothenburg University, Sweden
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- Cavanagh, J. P. (author)
- Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway
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- Stensen, W. (author)
- UiT The Arctic University of Norway, Norway
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- Mortensen, B. (author)
- Amicoat A/S, Norway
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- Svenson, Johan (author)
- RISE,Cawthron Institute, New Zealand
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Svenson, J. (author)
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(creator_code:org_t)
- 2021-01-25
- 2021
- English.
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In: Journal of Antibiotics. - : Springer Science and Business Media LLC. - 0021-8820 .- 1881-1469. ; 74, s. 337-345
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Abstract
Subject headings
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- Synthetic mimics of antimicrobial peptides (AMPs) is a promising class of molecules for a variety of antimicrobial applications. Several hurdles must be passed before effective systemic infection therapies with AMPs can be achieved, but the path to effective topical treatment of skin, nail, and soft tissue infections appears less challenging to navigate. Skin and soft tissue infection is closely coupled to the emergence of antibiotic resistance and represents a major burden to the healthcare system. The present study evaluates the promising synthetic cationic AMP mimic, AMC-109, for treatment of skin infections in vivo. The compound is evaluated both in impregnated cotton wound dressings and in a gel formulation against skin infections caused by Staphylococcus aureus and methicillin resistant S. aureus. Both the ability to prevent colonization and formation of an infection, as well as eradicate an ongoing infection in vivo with a high bacterial load, were evaluated. The present work demonstrates that AMC-109 displays a significantly higher antibacterial activity with up to a seven-log reduction in bacterial loads compared to current clinical standard therapy; Altargo cream (1% retapamulin) and Fucidin cream (2% fusidic acid) in the in vivo wound models. It is thus concluded that AMC-109 represents a promising entry in the development of new and effective remedies for various skin infections.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- cationic antimicrobial peptides
- methicillin-resistant
- staphylococcus-aureus
- mouse model
- skin
- peptidomimetics
- antibiotics
- infections
- stability
- efficacy
- Biotechnology & Applied Microbiology
- Immunology
- Microbiology
- Pharmacology & Pharmacy
Publication and Content Type
- ref (subject category)
- art (subject category)
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