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Biomarker support f...
Biomarker support for ADHD diagnosis based on Event Related Potentials and scores from an attention test
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- Häger, Linda Angelica (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Åsberg Johnels, Jakob, 1978 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Institutionen för neurovetenskap och fysiologi,Gillberg Neuropsychiatry Centre,Institute of Neuroscience and Physiology
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Kropotov, J. D. (author)
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Weidle, B. (author)
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Hollup, S. (author)
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Zehentbauer, P. G. (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Billstedt, Eva, 1961 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Ogrim, Geir (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Psychiatry Research. - : Elsevier BV. - 0165-1781. ; 300
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Abstract
Subject headings
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- ADHD is a heterogeneous neurodevelopmental disorder associated with dysfunctions in several brain systems. Objective markers of brain dysfunction for clinical assessment are lacking. Many studies applying electroencephalography (EEG) and neuropsychological tests find significant differences between ADHD and controls, but the effect sizes (ES) are often too small for diagnostic purposes. This study aimed to compute a diagnostic index for ADHD by combining behavioral test scores from a cued visual go/no-go task and Event Related Potentials (ERPs). Sixty-one children (age 9-12 years) diagnosed with ADHD and 69 age- and gender-matched typically developing children (TDC) underwent EEG-recording while tested on a go/no-go task. Based on comparisons of ERP group-means and task-performance, variables that differed significantly between the groups with at least moderate ES were converted to a five points percentile scale and multiplied by the ES of the variable. The sum-scores of the variables constituted the diagnostic index. The index discriminated significantly between patients and TDC with a large ES. This index was applied to an independent sample (20 ADHD, 21 TDC), distinguishing the groups with an even larger ES. The diagnostic index described has the potential to support assessment. Further research establishing diagnostic indexes for differential diagnoses is needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- ADHD
- Event related potentials
- Biomarkers
- Children
- Win EEG
- Electrophysiology
- Diagnostic index
- deficit/hyperactivity disorder
- executive function
- children
- eeg
- adolescents
- schizophrenia
- reliability
- artifacts
- validity
- deficit
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Häger, Linda Ang ...
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Åsberg Johnels, ...
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Kropotov, J. D.
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Weidle, B.
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Hollup, S.
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Zehentbauer, P. ...
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show more...
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Gillberg, Christ ...
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Billstedt, Eva, ...
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Ogrim, Geir
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Psychiatry Resea ...
- By the university
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University of Gothenburg