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Single-nuclei trans...
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
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- Bedoya-Reina, O. C. (author)
- Karolinska Institutet
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- Li, W. (author)
- Karolinska Institutet
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- Arceo, M. (author)
- Karolinska Institutet
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Plescher, M. (author)
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- Bullova, P. (author)
- Karolinska Institutet
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Pui, H. (author)
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Kaucka, M. (author)
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Kharchenko, P. (author)
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- Martinsson, Tommy, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Holmberg, J. (author)
- Karolinska Institutet
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- Adameyko, I. (author)
- Karolinska Institutet
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- Deng, Q. (author)
- Karolinska Institutet
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- Larsson, C. (author)
- Karolinska Institutet
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- Juhlin, C. C. (author)
- Karolinska Institutet
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- Kogner, P. (author)
- Karolinska Institutet
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- Schlisio, S. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-07
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Abstract
Subject headings
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- Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of neuroblastoma with different clinical risk groups and stages, including healthy adrenal gland. We compare tumor cell populations with embryonic mouse sympatho-adrenal derivatives, and post-natal human adrenal gland. We provide evidence that low and high-risk neuroblastoma have different cell identities, representing two disease entities. Low-risk neuroblastoma presents a transcriptome that resembles sympatho- and chromaffin cells, whereas malignant cells enriched in high-risk neuroblastoma resembles a subtype of TRKB+ cholinergic progenitor population identified in human post-natal gland. Analyses of these populations reveal different gene expression programs for worst and better survival in correlation with age at diagnosis. Our findings reveal two cellular identities and a composition of human neuroblastoma tumors reflecting clinical heterogeneity and outcome. Childhood neuroblastoma can be separated into high and low risk groups, with prognosis depending on age at diagnosis. Here, the authors show that low and high risk neuroblastoma tumours are composed of different cell types with different malignancy potential.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- rna-seq
- heterogeneity
- landscape
- pathway
- chrna7
- cells
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bedoya-Reina, O. ...
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Li, W.
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Arceo, M.
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Plescher, M.
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Bullova, P.
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Pui, H.
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show more...
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Kaucka, M.
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Kharchenko, P.
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Martinsson, Tomm ...
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Holmberg, J.
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Adameyko, I.
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Deng, Q.
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Larsson, C.
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Juhlin, C. C.
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Kogner, P.
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Schlisio, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg
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Karolinska Institutet