SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:gup.ub.gu.se/311124"
 

Search: id:"swepub:oai:gup.ub.gu.se/311124" > EANM dosimetry comm...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

EANM dosimetry committee series on standard operational procedures: a unified methodology for Tc-99m-MAA pre- and Y-90 peri-therapy dosimetry in liver radioembolization with Y-90 microspheres

Chiesa, C. (author)
Istituto Nazionale dei Tumori
Sjogreen-Gleisner, Katarina (author)
Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
Walrand, S. (author)
Catholic University of Louvain
show more...
Strigari, L. (author)
Flux, G. (author)
Institute of Cancer Research London
Gear, J. (author)
Institute of Cancer Research London
Stokke, C. (author)
Oslo university hospital
Gabina, Pablo Minguez (author)
Hospital de Cruces
Bernhardt, Peter, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences,Sahlgrenska University Hospital,Sahlgrenska Academy
Konijnenberg, M. (author)
Erasmus University Medical Center
show less...
 (creator_code:org_t)
2021-11-12
2021
English.
In: Ejnmmi Physics. - : Springer Science and Business Media LLC. - 2197-7364. ; 8:1
Related links:
https://ejnmmiphys.s...
show more...
http://dx.doi.org/10... (free)
https://gup.ub.gu.se...
https://doi.org/10.1...
https://lup.lub.lu.s...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in Y-90 microsphere liver radioembolization. Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel dosimetry, and the patient-relative calibration method for activity quantification.The identity of Tc-99m albumin macro-aggregates (MAA) and Y-90 microsphere biodistribution is also assumed. The large observed discrepancies in some patients between Tc-99m-MAA predictions and actual Y-90 microsphere distributions for lesions is discussed. Absorbed dose predictions to whole non-tumoural liver are considered more reliable and the basic predictors of toxicity. Treatment planning based on mean absorbed dose delivered to the whole non-tumoural liver is advised, except in super-selective treatments. Given the potential mismatch between MAA simulation and actual therapy, absorbed doses should be calculated both pre- and post-therapy. Distinct evaluation between target tumours and non-tumoural tissue, including lungs in cases of lung shunt, are vital for proper optimization of therapy. Dosimetry should be performed first according to a mean absorbed dose approach, with an optional, but important, voxel level evaluation. Fully corrected Tc-99m-MAA Single Photon Emission Computed Tomography (SPECT)/computed tomography (CT) and Y-90 TOF PET/CT are regarded as optimal acquisition methodologies, but, for institutes where SPECT/CT is not available, non-attenuation corrected Tc-99m-MAA SPECT may be used. This offers better planning quality than non dosimetric methods such as Body Surface Area (BSA) or mono-compartmental dosimetry. Quantitative Y-90 bremsstrahlung SPECT can be used if dedicated correction methods are available. The proposed methodology is feasible with standard camera software and a spreadsheet. Available commercial or free software can help facilitate the process and improve calculation time.

Subject headings

NATURVETENSKAP  -- Fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)

Keyword

Radioembolization dosimetry
Tc-99m-MAA
Y-90 microspheres
Lung shunt
Liver dosimetry
Tumour dosimetry
Y-90 PET
Prospective
retrospective
dosimetry
selective internal radiotherapy
voxel s-values
hepatocellular-carcinoma
glass microspheres
radiation-therapy
partition model
tc-99m-macroaggregated albumin
bremsstrahlung
spect/ct
image-reconstruction
quantitative spect
Radiology
Nuclear Medicine & Medical Imaging
Y microspheres
Y PET
Tc-MAA
Prospective/retrospective dosimetry

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view