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Sökning: id:"swepub:oai:gup.ub.gu.se/311124" > EANM dosimetry comm...

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FältnamnIndikatorerMetadata
00006411naa a2200841 4500
001oai:gup.ub.gu.se/311124
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:c85ad542-9eea-4141-8b53-5ce21467330c
0247 a https://gup.ub.gu.se/publication/3111242 URI
0247 a https://doi.org/10.1186/s40658-021-00394-32 DOI
0247 a https://lup.lub.lu.se/record/c85ad542-9eea-4141-8b53-5ce21467330c2 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chiesa, C.u Istituto Nazionale dei Tumori4 aut
2451 0a EANM dosimetry committee series on standard operational procedures: a unified methodology for Tc-99m-MAA pre- and Y-90 peri-therapy dosimetry in liver radioembolization with Y-90 microspheres
264 c 2021-11-12
264 1b Springer Science and Business Media LLC,c 2021
520 a The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in Y-90 microsphere liver radioembolization. Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel dosimetry, and the patient-relative calibration method for activity quantification.The identity of Tc-99m albumin macro-aggregates (MAA) and Y-90 microsphere biodistribution is also assumed. The large observed discrepancies in some patients between Tc-99m-MAA predictions and actual Y-90 microsphere distributions for lesions is discussed. Absorbed dose predictions to whole non-tumoural liver are considered more reliable and the basic predictors of toxicity. Treatment planning based on mean absorbed dose delivered to the whole non-tumoural liver is advised, except in super-selective treatments. Given the potential mismatch between MAA simulation and actual therapy, absorbed doses should be calculated both pre- and post-therapy. Distinct evaluation between target tumours and non-tumoural tissue, including lungs in cases of lung shunt, are vital for proper optimization of therapy. Dosimetry should be performed first according to a mean absorbed dose approach, with an optional, but important, voxel level evaluation. Fully corrected Tc-99m-MAA Single Photon Emission Computed Tomography (SPECT)/computed tomography (CT) and Y-90 TOF PET/CT are regarded as optimal acquisition methodologies, but, for institutes where SPECT/CT is not available, non-attenuation corrected Tc-99m-MAA SPECT may be used. This offers better planning quality than non dosimetric methods such as Body Surface Area (BSA) or mono-compartmental dosimetry. Quantitative Y-90 bremsstrahlung SPECT can be used if dedicated correction methods are available. The proposed methodology is feasible with standard camera software and a spreadsheet. Available commercial or free software can help facilitate the process and improve calculation time.
650 7a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
653 a Radioembolization dosimetry
653 a Tc-99m-MAA
653 a Y-90 microspheres
653 a Lung shunt
653 a Liver dosimetry
653 a Tumour dosimetry
653 a Y-90 PET
653 a Prospective
653 a retrospective
653 a dosimetry
653 a selective internal radiotherapy
653 a voxel s-values
653 a hepatocellular-carcinoma
653 a glass microspheres
653 a radiation-therapy
653 a partition model
653 a tc-99m-macroaggregated albumin
653 a bremsstrahlung
653 a spect/ct
653 a image-reconstruction
653 a quantitative spect
653 a Radiology
653 a Nuclear Medicine & Medical Imaging
653 a Y microspheres
653 a Y PET
653 a Tc-MAA
653 a Prospective/retrospective dosimetry
7001 a Sjogreen-Gleisner, Katarinau Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)rafy-ksj
7001 a Walrand, S.u Catholic University of Louvain4 aut
7001 a Strigari, L.4 aut
7001 a Flux, G.u Institute of Cancer Research London4 aut
7001 a Gear, J.u Institute of Cancer Research London4 aut
7001 a Stokke, C.u Oslo university hospital4 aut
7001 a Gabina, Pablo Minguezu Hospital de Cruces4 aut0 (Swepub:lu)pa5002mi
7001 a Bernhardt, Peter,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences,Sahlgrenska University Hospital,Sahlgrenska Academy4 aut0 (Swepub:gu)xbernp
7001 a Konijnenberg, M.u Erasmus University Medical Center4 aut
7102 a Istituto Nazionale dei Tumorib Medicinsk strålningsfysik, Lund4 org
7730 t Ejnmmi Physicsd : Springer Science and Business Media LLCg 8:1q 8:1x 2197-7364
8564 u https://ejnmmiphys.springeropen.com/track/pdf/10.1186/s40658-021-00394-3
8564 u http://dx.doi.org/10.1186/s40658-021-00394-3x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/311124
8564 8u https://doi.org/10.1186/s40658-021-00394-3
8564 8u https://lup.lub.lu.se/record/c85ad542-9eea-4141-8b53-5ce21467330c

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