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Combined metabolic ...
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients
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- Zeybel, M. (author)
- Nottingham University Hospitals NHS Trust,University Of Nottingham,Koc Universitesi,Koç University,Nottingham Univ Hosp NHS Trust, NIHR Nottingham Biomed Res Ctr, Nottingham, England.;Univ Nottingham, Nottingham, England.;Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Nottingham, England.;Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, Istanbul, Turkey.
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- Altay, Özlem (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Arif, Muhammad (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Li, Xiangyu (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Yang, Hong (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Fredolini, Claudia (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Akyildiz, M. (author)
- Koc Universitesi,Koç University,Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, Istanbul, Turkey.
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- Saglam, B. (author)
- Koc Universitesi,Koç University,Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, Istanbul, Turkey.
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- Gonenli, M. G. (author)
- Koc Universitesi,Koç University,Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, Istanbul, Turkey.
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- Ural, D. (author)
- Koc Universitesi,Koç University,Koc Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
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- Kim, Woonghee (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Zhang, C. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Shoaie, Saeed, 1985 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Albanova VinnExcellence Center for Protein Technology, ProNova,Systembiologi
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
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- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.
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(creator_code:org_t)
- 2021-10-25
- 2021
- English.
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In: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 17:10
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Abstract
Subject headings
Close
- Nonalcoholic fatty liver disease (NAFLD) refers to excess fat accumulation in the liver. In animal experiments and human kinetic study, we found that administration of combined metabolic activators (CMAs) promotes the oxidation of fat, attenuates the resulting oxidative stress, activates mitochondria, and eventually removes excess fat from the liver. Here, we tested the safety and efficacy of CMA in NAFLD patients in a placebo-controlled 10-week study. We found that CMA significantly decreased hepatic steatosis and levels of aspartate aminotransferase, alanine aminotransferase, uric acid, and creatinine, whereas found no differences on these variables in the placebo group after adjustment for weight loss. By integrating clinical data with plasma metabolomics and inflammatory proteomics as well as oral and gut metagenomic data, we revealed the underlying molecular mechanisms associated with the reduced hepatic fat and inflammation in NAFLD patients and identified the key players involved in the host-microbiome interactions. In conclusion, we showed that CMA can be used to develop a pharmacological treatment strategy in NAFLD patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- CMA
- multi-omics
- NAFLD
- systems biology
- hepatic steatosis
- perspectives
- nash
- diet
- Biochemistry & Molecular Biology
- multi-omics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Zeybel, M.
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Altay, Özlem
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Arif, Muhammad
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Li, Xiangyu
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Yang, Hong
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Fredolini, Claud ...
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show more...
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Akyildiz, M.
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Saglam, B.
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Gonenli, M. G.
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Ural, D.
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Kim, Woonghee
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Schwenk, Jochen ...
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Zhang, C.
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Shoaie, Saeed, 1 ...
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Nielsen, Jens B, ...
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Uhlén, Mathias
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Borén, Jan, 1963
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Mardinoglu, Adil ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Molecular System ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Royal Institute of Technology