Understanding the role of endotoxin tolerance in chronic inflammatory conditions and periodontal disease.

Larsson, Lena, 1969 (author): Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2

Garaicoa-Pazmino, Carlos (author)

Asa'ad, Farah, 1983 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institutionen för odontologi,Institute of Clinical Sciences, Department of Biomaterials,Institute of Odontology

Castilho, Rogerio M (author)

(creator_code:org_t)

2022-01-07
2021
English.
In: Journal of clinical periodontology. - : Wiley. - 1600-051X .- 0303-6979. ; 49:3, s. 270-279

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

This review aims to present the current understanding of endotoxin tolerance (ET) in chronic inflammatory diseases and explores the potential connection with periodontitis.Subsequent exposure to lipopolysaccharides (LPS) triggers ET, a phenomenon regulated by different mechanisms and pathways, including toll-like receptors (TLRs), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), apoptosis of immune cells, epigenetics, and microRNAs (miRNAs). These mechanisms interconnect ET with chronic inflammatory diseases that include periodontitis. While the direct correlation between ET and periodontal destruction has not been fully elucidated, emerging reports point towards the potential tolerization of human periodontal ligament cells (hPDLCs) and gingival tissues with a significant reduction of TLR levels.There is a potential link between ET and periodontal diseases. Future studies should explore the crucial role of ET in the pathogenesis of periodontal diseases as evidence of a tolerized oral mucosa may represent an intrinsic mechanism capable of regulating the oral immune response. A clear understanding of this host immune regulatory mechanism might lead to effective and more predictable therapeutic strategies to treat chronic inflammatory diseases and periodontitis. This article is protected by copyright. All rights reserved.

By the author/editor: Larsson, Lena, 1 ...; Garaicoa-Pazmino ...; Asa'ad, Farah, 1 ...; Castilho, Rogeri ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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