id:"swepub:oai:gup.ub.gu.se/313347"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02963naa a2200433 4500 | |
| 001 | oai:gup.ub.gu.se/313347 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3133472 URI |
| 024 | 7 | a https://doi.org/10.1039/d1sc05278k2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a He, Xiulanu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xhexid |
| 245 | 1 0 | a Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells |
| 264 | c 2022 | |
| 264 | 1 | b Royal Society of Chemistry (RSC),c 2022 |
| 520 | a Activity-induced synaptic plasticity has been intensively studied, but is not yet well understood. We examined the temporal and concentration effects of exocytotic molecular plasticity during and immediately after chemical stimulation (30 s K+ stimulation) via single cell amperometry. Here the first and the second 15 s event periods from individual event traces were compared. Remarkably, we found that the amount of catecholamine release and release dynamics depend on the stimulant concentration. No changes were observed at 10 mM K+ stimulation, but changes observed at 30 and 50 mM (i.e., potentiation, increased number of molecules) were opposite to those at 100 mM (i.e., depression, decreased number of events), revealing changes in exocytotic plasticity based on the concentration of the stimulant solution. These results show that molecular changes initiating exocytotic plasticity can be regulated by the concentration strength of the stimulant solution. These different effects on early plasticity offer a possible link between stimulation intensity and synaptic (or adrenal) plasticity. | |
| 650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
| 653 | a calcium-dependent exocytosis | |
| 653 | a protein-kinase-c | |
| 653 | a synaptic plasticity | |
| 653 | a quantal size | |
| 653 | a chromaffin cells | |
| 653 | a fusion pore | |
| 653 | a short-term | |
| 653 | a membrane | |
| 653 | a release | |
| 653 | a dynamin | |
| 653 | a Chemistry | |
| 700 | 1 | a Ewing, Andrew G,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xewian |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Chemical Scienced : Royal Society of Chemistry (RSC)g 13, s. 1815-1822q 13<1815-1822x 2041-6520x 2041-6539 |
| 856 | 4 | u https://pubs.rsc.org/en/content/articlepdf/2022/sc/d1sc05278k |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/313347 |
| 856 | 4 8 | u https://doi.org/10.1039/d1sc05278k |
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