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Obesity and the Ris...
Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults
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Jaakonmäki, N. (author)
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Zedde, M. (author)
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Sarkanen, T. (author)
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Martinez-Majander, N. (author)
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Tuohinen, S. (author)
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Sinisalo, J. (author)
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Ryödi, E. (author)
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Autere, J. (author)
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Hedman, M. (author)
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Junttola, U. (author)
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Huhtakangas, J. K. (author)
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Grimaldi, T. (author)
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Pascarella, R. (author)
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- Nordanstig, Annika, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Bech-Hanssen, O. (author)
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Holbe, C. (author)
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Busch, R. (author)
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Fromm, A. (author)
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Ylikotila, P. (author)
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Turgut, E. E. (author)
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Amorim, I. (author)
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Ryliskiene, K. (author)
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Tulkki, L. (author)
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Pascasio, L. A. (author)
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Licenik, R. (author)
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Ferdinand, P. (author)
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Tsivgoulis, G. (author)
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Jatužis, D. (author)
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Kõrv, L. (author)
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Kõrv, J. (author)
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Pezzini, A. (author)
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Fonseca, A. C. (author)
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Yesilot, N. (author)
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Roine, R. O. (author)
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Waje-Andreassen, U. (author)
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von Sarnowski, B. (author)
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- Redfors, Petra (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Huhtakangas, J. (author)
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Numminen, H. (author)
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Jäkälä, P. (author)
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Putaala, J. (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Journal of Stroke and Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 31:5
- Related links:
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http://www.strokejou...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and Methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors. © 2022 The Author(s)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Cryptogenic stroke
- Ischemic stroke
- Obesity
- Waist-to-hip ratio
- Young adults
- abdominal obesity
- adult
- Article
- body build
- body height
- body mass
- body weight
- cardiovascular risk
- case control study
- confounding variable
- controlled study
- cryptogenic ischemic stroke
- demographics
- educational status
- female
- hip circumference
- human
- major clinical study
- male
- migraine with aura
- odds ratio
- prospective study
- risk factor
- sex
- waist circumference
- waist hip ratio
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Jaakonmäki, N.
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Zedde, M.
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Sarkanen, T.
-
Martinez-Majande ...
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Tuohinen, S.
-
Sinisalo, J.
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show more...
-
Ryödi, E.
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Autere, J.
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Hedman, M.
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Junttola, U.
-
Huhtakangas, J. ...
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Grimaldi, T.
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Pascarella, R.
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Nordanstig, Anni ...
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Bech-Hanssen, O.
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Holbe, C.
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Busch, R.
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Fromm, A.
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Ylikotila, P.
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Turgut, E. E.
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Amorim, I.
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Ryliskiene, K.
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Tulkki, L.
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Pascasio, L. A.
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Licenik, R.
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Ferdinand, P.
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Tsivgoulis, G.
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Jatužis, D.
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Kõrv, L.
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Kõrv, J.
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Pezzini, A.
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Fonseca, A. C.
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Yesilot, N.
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Roine, R. O.
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Waje-Andreassen, ...
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von Sarnowski, B ...
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Redfors, Petra
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Huhtakangas, J.
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Numminen, H.
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Jäkälä, P.
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Putaala, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Strok ...
- By the university
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University of Gothenburg