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Sex Disparities in ...
Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies
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- Zhang, Guo-Qiang (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Ermis, Özuygur, 1991 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Rådinger, Madeleine, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Bossios, A. (författare)
- Karolinska Institutet
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- Kankaanranta, Hannu, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Nwaru, Bright I, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: Journal of Asthma and Allergy. - 1178-6965. ; 15, s. 231-247
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- A gender-related disparity exists in asthma morbidity and mortality, which shifts at around puberty from a male predominance to a female predominance. This is clinically reflected in the fact that asthma that occurs in childhood (childhoodonset asthma) mainly affects boys, and that asthma that occurs in adulthood (adult-onset asthma) mainly affects women. Adult-onset asthma is often non-atopic, more severe, and associated with a poorer prognosis, thus posing a marked burden to women’s health and healthcare system. Many factors have been indicated to explain this gender-related disparity, including sociocultural and environmental factors as well as biological sex differences (genetic, pulmonary and immunological factors). It has long been suggested that sex hormones may be implicated in at least these biological sex differences. Overall, the evidence remains equivocal for the role of most sex hormones in asthma pathogenesis and clinical outcomes. Well-designed randomized clinical trials are required assessing the potential preventive or therapeutic effects of hormonal contraceptives on asthma in women, thereby helping to advance the evidence to inform future practice guidelines. The mechanisms underlying the role of sex hormones in asthma are complex, and our understanding is not yet complete. Additional mechanistic studies elucidating sex hormone signaling pathways and their interactions involved in the pathogenesis and clinical manifestations of asthma will help to identify potential sex hormone-driven asthma endotypes and novel therapeutic targets, providing the basis for a more personalized asthma management strategy. © 2022 Zhang et al.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Androgen
- Asthma
- Estrogen
- Progestogen
- Sex disparity
- Sex hormone
- hormonal contraceptive agent
- progesterone
- testosterone
- adult onset asthma
- adulthood
- atopy
- childhood
- childhood onset asthma
- clinical outcome
- disease course
- environmental factor
- eosinophil
- female
- hormone substitution
- human
- inflammation
- male
- menopause
- menstruation
- morbidity
- mortality
- neutrophil
- pathogenesis
- pregnancy
- prognosis
- puberty
- Review
- risk factor
- sex difference
- signal transduction
- social background
- testosterone blood level
- therapy effect
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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