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Validation of DIGIR...
Validation of DIGIROP models and decision support tool for prediction of treatment for retinopathy of prematurity on a contemporary Swedish cohort
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- Pivodic, Aldina, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sweden,Sahlgrenska Academy
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- Larsson, Eva, 1961- (författare)
- Uppsala universitet,Uppsala University,Söderberg: Oftalmiatrik
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- Hård, Anna-Lena, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sweden,Sahlgrenska Academy
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- Löfqvist, Chatarina, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden,Sahlgrenska Academy
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- Almeida, A. C. (författare)
- Hosp Beatriz Angelo, Portugal; Hosp Sao Francisco Xavier, Portugal; Univ Nova Lisboa, Portugal; Univ Nova Lisboa, Portugal; Hosp Luz, Portugal,Centro Hospitalar de Lisboa Ocidental (CHLO),NOVA University Lisbon
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- Al-Hawasi, Abbas, 1976- (författare)
- Linköping University,Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten
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Larsson, E. (författare)
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- Lundgren, Pia, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sweden,Sahlgrenska Academy
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- Sunnqvist, B. (författare)
- Lanssjukhuset Ryhov, Sweden,Ryhov County Hospital, Jönköping
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- Tornqvist, Kristina (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Wallin, A. (författare)
- St Erik Eye Hosp, Sweden,St Erik Eye Hospital
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- Holmström, Gerd, 1951- (författare)
- Uppsala universitet,Uppsala University,Söderberg: Oftalmiatrik
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- Gränse, Lotta (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning kring familjer med ärftliga näthinnesjukdomar,Forskargrupper vid Lunds universitet,Retinopathy of Prematurity,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical research in families with inherited retinal degeneration,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2022-03-11
- 2023
- Engelska.
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Ingår i: British Journal of Ophthalmology. - : BMJ. - 0007-1161 .- 1468-2079. ; 107:8, s. 1132-1138
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background/Aims Retinopathy of prematurity (ROP) is currently diagnosed through repeated eye examinations to find the low percentage of infants that fulfil treatment criteria to reduce vision loss. A prediction model for severe ROP requiring treatment that might sensitively and specifically identify infants that develop severe ROP, DIGIROP-Birth, was developed using birth characteristics. DIGIROP-Screen additionally incorporates first signs of ROP in different models over time. The aim was to validate DIGIROP-Birth, DIGIROP-Screen and their decision support tool on a contemporary Swedish cohort. Methods Data were retrieved from the Swedish national registry for ROP (2018-2019) and two Swedish regions (2020), including 1082 infants born at gestational age (GA) 24 to <31 weeks. The predictors were GA at birth, sex, standardised birth weight and age at the first sign of ROP. The outcome was ROP treatment. Sensitivity, specificity and area under the receiver operating characteristic curve (AUC) with 95% CI were described. Results For DIGIROP-Birth, the AUC was 0.93 (95% CI 0.90 to 0.95); for DIGIROP-Screen, it ranged between 0.93 and 0.97. The specificity was 49.9% (95% CI 46.7 to 53.0) and the sensitivity was 96.5% (95% CI 87.9 to 99.6) for the tool applied at birth. For DIGIROP-Screen, the cumulative specificity ranged between 50.0% and 78.7%. One infant with Beckwith-Wiedemann syndrome who fulfilled criteria for ROP treatment and had no missed/incomplete examinations was incorrectly flagged as not needing screening. Conclusions DIGIROP-Birth and DIGIROP-Screen showed high predictive ability in a contemporary Swedish cohort. At birth, 50% of the infants born at 24 to <31 weeks of gestation were predicted to have low risk of severe ROP and could potentially be released from ROP screening examinations. All routinely screened treated infants, excluding those screened for clinical indications of severe illness, were correctly flagged as needing ROP screening.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- diagnostic tests
- investigation
- retina
- postnatal weight-gain
- warranted retinopathy
- birth-weight
- risk
- applicability
- probast
- bias
- Ophthalmology
- diagnostic tests; investigation; retina
- diagnostic tests/investigation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pivodic, Aldina, ...
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Larsson, Eva, 19 ...
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Hård, Anna-Lena, ...
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Löfqvist, Chatar ...
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Almeida, A. C.
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Al-Hawasi, Abbas ...
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visa fler...
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Larsson, E.
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Lundgren, Pia, 1 ...
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Sunnqvist, B.
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Tornqvist, Krist ...
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Wallin, A.
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Holmström, Gerd, ...
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Gränse, Lotta
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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British Journal ...
- Av lärosätet
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Göteborgs universitet
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Linköpings universitet
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Lunds universitet
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