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Sökning: id:"swepub:oai:gup.ub.gu.se/316434" > Severe intraventric...

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FältnamnIndikatorerMetadata
00006223naa a2200589 4500
001oai:gup.ub.gu.se/316434
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:faefc4fa-5ba3-4926-99fe-d7ddffe8cef7
0247 a https://gup.ub.gu.se/publication/3164342 URI
0247 a https://doi.org/10.1038/s41390-022-02075-y2 DOI
0247 a https://lup.lub.lu.se/record/faefc4fa-5ba3-4926-99fe-d7ddffe8cef72 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Romantsik, Olgau Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-oar
2451 0a Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model
264 c 2022-05-03
264 1b Springer Science and Business Media LLC,c 2022
520 a Background Intraventricular hemorrhage causes significant lifelong mortality and morbidity, especially in preterm born infants. Progress in finding an effective therapy is stymied by a lack of preterm animal models with long-term follow-up. This study addresses this unmet need, using an established model of preterm rabbit IVH and analyzing outcomes out to 1 month of age. Methods Rabbit pups were delivered preterm and administered intraperitoneal injection of glycerol at 3 h of life and approximately 58% developed IVH. Neurobehavioral assessment was performed at 1 month of age followed by immunohistochemical labeling of epitopes for neurons, synapses, myelination, and interneurons, analyzed by means of digital quantitation and assessed via two-way ANOVA or Student's t test. Results IVH pups had globally reduced myelin content, an aberrant cortical myelination microstructure, and thinner upper cortical layers (I-III). We also observed a lower number of parvalbumin (PV)-positive interneurons in deeper cortical layers (IV-VI) in IVH animals and reduced numbers of neurons, synapses, and microglia. However, there were no discernable changes in behaviors. Conclusions We have established in this preterm pup model that long-term changes after IVH include significant wide-ranging alterations to cortical organization and microstructure. Further work to improve the sensitivity of neurocognitive testing in this species at this age may be required. Impact This study uses an established animal model of preterm birth, in which the rabbit pups are truly born preterm, with reduced organ maturation and deprivation of maternally supplied trophic factors. This is the first study in preterm rabbits that explores the impacts of severe intraventricular hemorrhage beyond 14 days, out to 1 month of age. Our finding of persisting but subtle global changes including brain white and gray matter will have impact on our understanding of the best path for therapy design and interventions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a white-matter injury
653 a birth-weight infants
653 a growth restriction
653 a premature
653 a rabbits
653 a brain-development
653 a germinal matrix
653 a children born
653 a hydrocephalus
653 a myelination
653 a maturation
653 a Pediatrics
7001 a Ross-Munro, E.u RMIT University4 aut
7001 a Grönlund, Susanneu Lund University,Lunds universitet,Antioxidationsmedicin,Forskargrupper vid Lunds universitet,Antioxidation medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-sug
7001 a Holmqvist, B.u ImaGene-iT AB4 aut
7001 a Brinte, A.u ImaGene-iT AB4 aut
7001 a Gerdtsson, E.u ImaGene-iT AB4 aut
7001 a Vallius, Suviu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-svv
7001 a Bruschettini, Matteou Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mb14
7001 a Wang, Xiaoyang,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Sahlgrenska Academy,Zhengzhou University4 aut0 (Swepub:lu)xi6668wa
7001 a Fleiss, B.u RMIT University,Université Paris Cité4 aut
7001 a Ley, Davidu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,LTH profilområde: Avancerade ljuskällor,LTH profilområden,Lunds Tekniska Högskola,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,Skåne University Hospital4 aut0 (Swepub:lu)pedi-dle
7102 a Neonatalogib Forskargrupper vid Lunds universitet4 org
7730 t Pediatric Researchd : Springer Science and Business Media LLCg 92:2, s. 403-414q 92:2<403-414x 0031-3998x 1530-0447
8564 u http://dx.doi.org/10.1038/s41390-022-02075-yx freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/316434
8564 8u https://doi.org/10.1038/s41390-022-02075-y
8564 8u https://lup.lub.lu.se/record/faefc4fa-5ba3-4926-99fe-d7ddffe8cef7

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