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Correlation of tumo...
Correlation of tumour subtype with long-term outcome in small breast carcinomas: a Swedish population-based retrospective cohort study
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- Rask, Gunilla (author)
- Umeå universitet,Patologi,Kirurgi,Umeå Univ, Dept Med Biosci Pathol, Umeå, Sweden.;Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Nazemroaya, Anoosheh (author)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci Pathol, Umeå, Sweden.
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- Jansson, Malin (author)
- Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Wadsten, Charlotta (author)
- Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Nilsson, Greger (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Gävle Cent Hosp, Dept Oncol, Gävle, Sweden.;Visby Hosp, Dept Oncol, Visby, Sweden.
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- Blomqvist, C. (author)
- Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Oncology, Örebro University Hospital, Örebro, Sweden,Univ Helsinki, Dept Oncol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Örebro Univ Hosp, Dept Oncol, Örebro, Sweden.
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- Holmberg, Lars (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, London, England.
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- Wärnberg, Fredrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Clinical Sciences, Department of Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Surg, Dept Clin Sci, Gothenburg, Sweden.
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- Sund, Malin (author)
- Umeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Dept Surg, Helsinki, Finland.
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(creator_code:org_t)
- 2022-08-06
- 2022
- English.
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In: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 195:3, s. 367-377
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Abstract
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- Purpose To investigate if molecular subtype is associated with outcome in stage 1 breast cancer (BC). Methods Tissue samples from 445 women with node-negative BC <= 15 mm, treated in 1986-2004, were classified into surrogate molecular subtypes [Luminal A-like, Luminal B-like (HER2-), HER2-positive, and triple negative breast cancer (TNBC)]. Information on treatment, recurrences, and survival were gathered from medical records. Results Tumour subtype was not associated with overall survival (OS). Luminal B-like (HER2-) and TNBC were associated with higher incidence of distant metastasis at 20 years (Hazard ratio (HR) 2.26; 95% CI 1.08-4.75 and HR 3.24; 95% CI 1.17-9.00, respectively). Luminal B-like (HER2-) and TNBC patients also had worse breast cancer-specific survival (BCSS), although not statistically significant (HR 1.53; 95% CI 0.70-3.33 and HR 1.89; 95% CI 0.60-5.93, respectively). HER2-positive BC was not associated with poor outcome despite no patient receiving HER2-targeted therapy, with most of these tumours being ER+. Conclusions Stage 1 TNBC or Luminal B-like (HER2-) tumours behave more aggressively. Women with HER2+/ER+ tumours do not have an increased risk of distant metastasis or death, absent targeted treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- Molecular subtypes
- TMA
- Long-term outcome
- adjuvant chemotherapy
- cancer subtypes
- receptors
- estrogen
- immunohistochemistry
- heterogeneity
- amplification
- antigenicity
- trastuzumab
- expression
- Oncology
- Breast cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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