Sökning: id:"swepub:oai:gup.ub.gu.se/323230" > Assessment of the g...
Fältnamn | Indikatorer | Metadata |
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000 | 04857naa a2200673 4500 | |
001 | oai:gup.ub.gu.se/323230 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-200666 | |
024 | 7 | a https://gup.ub.gu.se/publication/3232302 URI |
024 | 7 | a https://doi.org/10.1016/j.xcrm.2022.1007762 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2006662 URI |
040 | a (SwePub)gud (SwePub)umu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nethander, Maria,d 1980u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xnetma |
245 | 1 0 | a Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study. |
264 | 1 | b Elsevier BV,c 2022 |
520 | a Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture is unclear. Here, we perform a large-scale hip fracture genome-wide association study meta-analysis and Mendelian randomization study using five cohorts from European biobanks. The results show that five genetic signals associate with hip fractures. Among these, one signal associates with falls, but not with bone mineral density (BMD), while four signals are in loci known to be involved in bone biology. Mendelian randomization analyses demonstrate a strong causal effect of decreased femoral neck BMD and moderate causal effects of Alzheimer's disease and having ever smoked regularly on risk of hip fractures. The substantial causal effect of decreased femoral neck BMD on hip fractures in both young and old subjects and in both men and women supports the use of change in femoral neck BMD as a surrogate outcome for hip fractures in clinical trials. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
653 | a Male | |
653 | a Female | |
653 | a Humans | |
653 | a Genome-Wide Association Study | |
653 | a Mendelian Randomization Analysis | |
653 | a Bone Density | |
653 | a genetics | |
653 | a Hip Fractures | |
653 | a epidemiology | |
653 | a Femur Neck | |
653 | a bone mineral density | |
700 | 1 | a Coward, Eivind4 aut |
700 | 1 | a Reimann, Ene4 aut |
700 | 1 | a Grahnemo, Louiseu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xstlou |
700 | 1 | a Gabrielsen, Maiken E4 aut |
700 | 1 | a Wibom, Carlu Umeå universitet,Onkologi4 aut0 (Swepub:umu)caewim02 |
700 | 1 | a Mägi, Reedik4 aut |
700 | 1 | a Funck-Brentano, Thomasu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xfunct |
700 | 1 | a Hoff, Mari4 aut |
700 | 1 | a Langhammer, Arnulf4 aut |
700 | 1 | a Pettersson-Kymmer, Ulrikau Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)ulpe0007 |
700 | 1 | a Hveem, Kristian4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Nelis, Mari4 aut |
700 | 1 | a Milani, Lili4 aut |
700 | 1 | a Esko, Tõnu4 aut |
700 | 1 | a Metspalu, Andres4 aut |
710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
773 | 0 | t Cell reports. Medicined : Elsevier BVg 3:10q 3:10x 2666-3791 |
856 | 4 | u https://doi.org/10.1016/j.xcrm.2022.100776y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1709066/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/323230 |
856 | 4 8 | u https://doi.org/10.1016/j.xcrm.2022.100776 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200666 |
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