id:"swepub:oai:gup.ub.gu.se/328612"
Search: id:"swepub:oai:gup.ub.gu.se/328612" > Clinical characteri...
- 1 of 1
- Previous record
- Next record
- To hitlist
Clinical characteristics and long-term neurodevelopmental outcomes of leukomalacia in preterm infants and term infants: a cohort study
- Song, J. (author)
- Yue, Y. Y. (author)
- Sun, H. Q. (author)
- show more...
- Cheng, P. (author)
- Xu, F. L. (author)
- Li, B. B. (author)
- Li, K. A. (author)
- show less...
- (creator_code:org_t)
- 2023
- 2023
- English.
- In: Journal of Neurodevelopmental Disorders. - 1866-1947 .- 1866-1955. ; 15:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BackgroundLeukomalacia is a serious form of neonatal brain injury that often leads to neurodevelopmental impairment, and studies on neonatal leukomalacia and its long-term outcomes are lacking. The aim of this study was to analyze the clinical manifestations, imaging features, and long-term neurodevelopmental outcomes in preterm infants and term infants with leukomalacia.MethodsNewborns diagnosed with leukomalacia by head magnetic resonance imaging (MRI) and who were admitted to intensive care units from January 2015 to June 2020 were enrolled. All infants were followed up to June 2022 (2-7 years old), and their neurodevelopmental outcomes were evaluated. The clinical data and long- term outcomes of preterm infants and term infants was analyzed by Chi-square tests.ResultsA total of 218 surviving infants with leukomalacia including 114 preterm infants and 104 term infants completed the follow-up. The major typesof leukomalacia on MRI were periventricular leukomalacia in the preterm group and subcortical cystic leukomalacia in the term group, respectively (& chi;(2) = 55.166; p < 0.001). When followed up to 2-7 years old, the incidence of neurodevelopmental impairment in the preterm group and term group was not significantly different (& chi;(2) = 0.917; p = 0.338). However, the incidence of cerebral palsy (CP) in the preterm group was significantly higher (& chi;(2) = 4.896; p = 0.027), while the incidence of intellectual disability (ID) (& chi;(2) = 9.445; p = 0.002), epilepsy (EP) (& chi;(2) = 23.049; p < 0.001), and CP combined with ID andEP (& chi;(2) = 4.122; p = 0.042) was significantly lower than that in the term group.ConclusionsPeriventricular leukomalacia mainly occurred in preterm infants while subcortical cystic leukomalacia was commonly seen in term infants. Although the long-term neurodevelopmental outcomes of leukomalacia were both poor, preterm infants were more prone to CP, while term infants were more prone to ID, EP, and the combination of CP with ID and EP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Leukomalacia
- Newborn
- Head MRI
- Neurodevelopmental outcomes
- Cerebral palsy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Journal of Neurodevelopmental Disorders (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Song, J.
- Yue, Y. Y.
- Sun, H. Q.
- Cheng, P.
- Xu, F. L.
- Li, B. B.
- show more...
- Li, K. A.
- Zhu, Changlian, ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Journal of Neuro ...
- By the university
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
