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Postnatal hyperglyc...
Postnatal hyperglycemia alters amino acid in retinas (model of Phase I ROP)
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Harman, J. C. (author)
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- Pivodic, Aldina, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Nilsson, Anders K., 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Boeck, M. (author)
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Yagi, H. (author)
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Neilsen, K. (author)
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Ko, M. J. (author)
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Yang, J. Y. (author)
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Kinter, M. (author)
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- Hellström, Ann, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Fu, Z. J. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Iscience. ; 26:10
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Amino acid supplementation reduces retinal neovascularization in mice. Little is known about amino acid contribution to Phase I ROP. In mice modeling hyperglycemia-associated Phase I ROP, we found significant changes in retinal amino acids (including most decreased L-leucine, L-isoleucine, and L-valine). Parenteral L-isoleucine suppressed physiological retinal vascularization. In premature infants, severe ROP was associated with a higher mean intake of parenteral versus enteral amino acids in the first two weeks of life after adjustment for treatment group, gestational age at birth, birth weight, and sex. The number of days with parenteral amino acids support independently predicted severe ROP. Further understanding and modulating amino acids may help improve nutritional intervention and prevent Phase I ROP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- total parenteral-nutrition
- oxygen-induced retinopathy
- endothelial
- growth-factor
- neonatal piglets
- weight-gain
- murine model
- infants
- mouse
- neovascularization
- requirement
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Harman, J. C.
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Pivodic, Aldina, ...
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Nilsson, Anders ...
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Boeck, M.
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Yagi, H.
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Neilsen, K.
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show more...
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Ko, M. J.
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Yang, J. Y.
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Kinter, M.
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Hellström, Ann, ...
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Fu, Z. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
- Articles in the publication
- Iscience
- By the university
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University of Gothenburg