Sökning: id:"swepub:oai:gup.ub.gu.se/331171" > Methotrexate safety...
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000 | 04097naa a2200505 4500 | |
001 | oai:gup.ub.gu.se/331171 | |
003 | SwePub | |
008 | 240528s2024 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:154689976 | |
024 | 7 | a https://gup.ub.gu.se/publication/3311712 URI |
024 | 7 | a https://doi.org/10.1002/art.427302 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1546899762 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lend, Kristinau Karolinska Institutet4 aut |
245 | 1 0 | a Methotrexate safety and efficacy in combination therapies in patients with early rheumatoid arthritis: a post-hoc analysis of a randomized controlled trial (NORD-STAR). |
264 | 1 | c 2024 |
520 | a To investigate methotrexate safety and influence of dose on efficacy outcomes in combination with three different biological treatments and with active conventional treatment (ACT) in early rheumatoid arthritis (RA).This post-hoc analysis included 812 treatment-naïve early RA patients who were randomized (1:1:1:1) in the NORD-STAR trial (NCT01491815) to receive methotrexate in combination with ACT, certolizumab-pegol, abatacept, or tocilizumab. Methotrexate safety, doses, and dose effects on Clinical Disease Activity Index (CDAI) remission were assessed after 24weeks of treatment.Compared with ACT, the prevalence of methotrexate-associated side effects was higher when methotrexate was combined with tocilizumab (HR 1.48 [95% CI 1.20 to 1.84]), but not with certolizumab-pegol (HR 0.99 [0.79 to 1.23]) or with abatacept (HR 0.93 [0.75 to 1.16]). With ACT as the reference, methotrexate dose was significantly lower when used in combination with tocilizumab (β -4.65 [95% CI -5.83 to -3.46], p<0.001), with abatacept (β -1.15 [-2.27 to -0.03], p=0.04), and numerically lower in combination with certolizumab-pegol (β -1.07 [-2.21 to 0.07], p=0.07). Methotrexate dose reductions were not associated with decreased CDAI remission rates within any of the treatment combinations.Methotrexate was generally well tolerated in combination therapies, but adverse events were a limiting factor in receiving the target dose of 25 mg/week, and these were more frequent in combination with tocilizumab versus active conventional treatment. On the other hand, methotrexate dose reductions were not associated with decreased CDAI remission rates within any of the four treatment combinations at 24weeks. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Koopman, Frieda A4 aut |
700 | 1 | a Lampa, Jonu Karolinska Institutet4 aut |
700 | 1 | a Jansen, Gerrit4 aut |
700 | 1 | a Hetland, Merete L4 aut |
700 | 1 | a Uhlig, Till4 aut |
700 | 1 | a Nordström, Dan4 aut |
700 | 1 | a Nurmohamed, Michael4 aut |
700 | 1 | a Gudbjornsson, Bjorn4 aut |
700 | 1 | a Rudin, Anna,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xrudan |
700 | 1 | a Østergaard, Mikkel4 aut |
700 | 1 | a Heiberg, Marte S4 aut |
700 | 1 | a Sokka-Isler, Tuulikki4 aut |
700 | 1 | a Hørslev-Petersen, Kim4 aut |
700 | 1 | a Haavardsholm, Espen A4 aut |
700 | 1 | a Grondal, Gerdur4 aut |
700 | 1 | a Twisk, Jos W R4 aut |
700 | 1 | a van Vollenhoven, Ronald4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
773 | 0 | t Arthritis & rheumatology (Hoboken, N.J.)g 76:3, s. 363-376q 76:3<363-376x 2326-5205 |
856 | 4 8 | u https://gup.ub.gu.se/publication/331171 |
856 | 4 8 | u https://doi.org/10.1002/art.42730 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:154689976 |
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