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Plasma p-tau231 and...
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
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Ferreira, P. C. L. (author)
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Therriault, J. (author)
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Tissot, C. (author)
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Ferrari-Souza, J. P. (author)
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- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Povala, G. (author)
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Bellaver, B. (author)
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Leffa, D. T. (author)
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Brum, W. S. (author)
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Lussier, F. Z. (author)
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Bezgin, G. (author)
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Servaes, S. (author)
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Vermeiren, M. (author)
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Macedo, A. C. (author)
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Cabrera, A. (author)
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Stevenson, J. (author)
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Triana-Baltzer, G. (author)
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Kolb, H. (author)
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Rahmouni, N. (author)
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Klunk, W. E. (author)
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Lopez, O. L. (author)
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Villemagne, V. L. (author)
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Cohen, A. (author)
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Tudorascu, D. L. (author)
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Zimmer, E. R. (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Blennow, K. (author)
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Gauthier, S. (author)
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Rosa-Neto, P. (author)
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Pascoal, T. A. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Alzheimers & Dementia. - 1552-5260. ; 19:10, s. 4463-4474
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https://doi.org/10.1...
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Abstract
Subject headings
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- INTRODUCTIONPhosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-& beta; (A & beta;) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify A & beta; and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI). METHODSWe assessed 138 CU and 87 CI with available plasma p-tau231, 217(+), and 181, A & beta;42/40, GFAP and A & beta;- and tau-PET. RESULTSIn CU, only plasma p-tau231 and p-tau217(+) significantly improved the performance of the demographics in detecting A & beta;-PET positivity, while no plasma biomarker provided additional information to identify tau-PET positivity. In CI, p-tau217(+) and GFAP significantly contributed to demographics to identify both A & beta;-PET and tau-PET positivity, while p-tau231 only provided additional information to identify tau-PET positivity. DISCUSSIONOur results support plasma p-tau231 and p-tau217(+) as state markers of early A & beta; deposition, but in later disease stages they inform on tau tangle accumulation. HighlightsIt is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex).Plasma p-tau231 and p-tau217(+) contribute to demographic information to identify brain A & beta; pathology in preclinical AD.In CI individuals, plasma p-tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p-tau217(+) and GFAP inform on both A & beta; deposition and tau pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- demographics
- PET
- plasma biomarkers
- p-tau
- tau pathology
- amyloid-beta
- alzheimers-disease
- neurofilament light
- biomarker
- association
- performance
- diagnosis
- kinetics
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Ferreira, P. C. ...
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Therriault, J.
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Tissot, C.
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Ferrari-Souza, J ...
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Lessa Benedet, A ...
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Povala, G.
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show more...
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Bellaver, B.
-
Leffa, D. T.
-
Brum, W. S.
-
Lussier, F. Z.
-
Bezgin, G.
-
Servaes, S.
-
Vermeiren, M.
-
Macedo, A. C.
-
Cabrera, A.
-
Stevenson, J.
-
Triana-Baltzer, ...
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Kolb, H.
-
Rahmouni, N.
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Klunk, W. E.
-
Lopez, O. L.
-
Villemagne, V. L ...
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Cohen, A.
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Tudorascu, D. L.
-
Zimmer, E. R.
-
Karikari, Thomas
-
Ashton, Nicholas ...
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Zetterberg, Henr ...
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Blennow, K.
-
Gauthier, S.
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Rosa-Neto, P.
-
Pascoal, T. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg