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Longitudinal interp...
Longitudinal interplay between subclinical atherosclerosis, cardiovascular risk factors, and cerebral glucose metabolism in midlife: results from the PESA prospective cohort study
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Tristao-Pereira, C. (författare)
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Fuster, V. (författare)
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Oliva, B. (författare)
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visa fler...
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Moreno-Arciniegas, A. (författare)
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Garcia-Lunar, I. (författare)
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Perez-Herreras, C. (författare)
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- Schöll, Michael, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Suárez-Calvet, M. (författare)
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Moro, M. A. (författare)
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Garcia-Alvarez, A. (författare)
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Fernandez-Ortiz, A. (författare)
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Sanchez-Gonzalez, J. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Ibanez, B. (författare)
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Gispert, J. (författare)
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Cortes-Canteli, M. (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Lancet Healthy Longevity. - 2666-7568. ; 4:9
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Cardiovascular disease and dementia often coexist at advanced stages. Yet, longitudinal studies examining the interplay between atherosclerosis and its risk factors on brain health in midlife are scarce. We aimed to characterise the longitudinal associations between cerebral glucose metabolism, subclinical atherosclerosis, and cardiovascular risk factors in middle-aged asymptomatic individuals. Methods The Progression of Early Subclinical Atherosclerosis (PESA) study is a Spanish longitudinal observational cohort study of 4184 asymptomatic individuals aged 40-54 years (NCT01410318). Participants with subclinical atherosclerosis underwent longitudinal cerebral [18F]fluorodeoxyglucose ([18F]FDG)-PET, and annual percentage change in [18F]FDG uptake was assessed (primary outcome). Cardiovascular risk was quantified with SCORE2 and subclinical atherosclerosis with three-dimensional vascular ultrasound (exposures). Multivariate regression and linear mixed effects models were used to assess associations between outcomes and exposures. Additionally, blood based biomarkers of neuropathology were quantified and mediation analyses were performed. Secondary analyses were corrected for multiple comparisons using the false discovery rate (FDR) approach. Findings This longitudinal study included a PESA subcohort of 370 participants (median age at baseline 49 & BULL;8 years [IQR 46 & BULL;1-52 & BULL;2]; 309 [84%] men, 61 [16%] women; median follow-up 4 & BULL;7 years [IQR 4 & BULL;2-5 & BULL;2]). Baseline scans took place between March 6, 2013, and Jan 21, 2015, and follow-up scans between Nov 24, 2017, and Aug 7, 2019. Persistent high risk of cardiovascular disease was associated with an accelerated decline of cortical [18F]FDG uptake compared with low risk (& beta;=-0 & BULL;008 [95% CI -0 & BULL;013 to -0 & BULL;002]; pFDR=0 & BULL;040), with plasma neurofilament light chain, a marker of neurodegeneration, mediating this association by 20% (& beta;=0 & BULL;198 [0 & BULL;008 to 0 & BULL;740]; pFDR=0 & BULL;050). Moreover, progression of subclinical carotid atherosclerosis was associated with an additional decline in [18F]FDG uptake in Alzheimer's disease brain regions, not explained by cardiovascular risk (& beta;=-0 & BULL;269 [95% CI -0 & BULL;509 to -0 & BULL;027]; p=0 & BULL;029). Interpretation Middle-aged asymptomatic individuals with persistent high risk of cardiovascular disease and subclinical carotid atherosclerosis already present brain metabolic decline, suggesting that maintenance of cardiovascular health during midlife could contribute to reductions in neurodegenerative disease burden later in life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- alzheimers-disease
- progression
- association
- Geriatrics & Gerontology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Tristao-Pereira, ...
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Fuster, V.
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Oliva, B.
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Moreno-Arciniega ...
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Garcia-Lunar, I.
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Perez-Herreras, ...
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visa fler...
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Schöll, Michael, ...
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Suárez-Calvet, M ...
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Moro, M. A.
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Garcia-Alvarez, ...
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Fernandez-Ortiz, ...
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Sanchez-Gonzalez ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Ibanez, B.
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Gispert, J.
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Cortes-Canteli, ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Gerontologi medi ...
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Göteborgs universitet