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Sökning: id:"swepub:oai:gup.ub.gu.se/332941" > A brief mind-body i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003766naa a2200397 4500
001oai:gup.ub.gu.se/332941
003SwePub
008240910s2023 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3329412 URI
0247 a https://doi.org/10.1016/j.urolonc.2023.09.0162 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gaffney, Christopher D.4 aut
2451 0a A brief mind-body intervention to reduce pain and anxiety during prostate needle biopsy: a clinically integrated randomized controlled trial with 2-staged consent
264 1c 2023
520 a Objectives: Many patients experience pain, anxiety, and discomfort with prostate biopsy, which may discourage enrollment in active surveillance programs or follow-up biopsy. Guided meditation can significantly reduce pain and anxiety during percutaneous biopsy. We sought to evaluate the effectiveness of a brief mind-body intervention on patient-reported outcomes after prostate biopsy. Methods and materials: We performed a clinically-integrated randomized controlled trial of a brief mind-body intervention during biopsy compared to usual care at a single tertiary care center from 2018 to 2022. All patients offered transrectal ultrasound-guided prostate biopsy in the clinic with local anesthesia were eligible for enrollment. This clinically integrated trial was conducted simultaneously with a randomized controlled trial of 1-stage and 2-stage consent. The primary outcome was patient-reported pain, anxiety, discomfort, and tolerability on a visual-analog scale (0–10). A 15% improvement was prespecified as clinically relevant. We compared the proportion of men in each arm reporting a severe score (7–10) on any of the 4 scales using Fisher's exact test and then compared means for each scale separately using ANCOVA with randomization stratum (first vs. prior biopsy) as a covariate. Results: Of 263 eligible patients, 238 enrolled (119 per arm). One hundred seventy-two (72%) enrolled with 2-stage consent. A total of 37/94 (39%) and 38/102 (37%) patients randomized to usual care and intervention, respectively, reported severe scores in any of the 4 domains, a difference of 2.1% (95% confidence interval [CI] -13, 17%, P = 0.8). There was no evidence of a difference in mean postbiopsy anxiety (P = 0.3), discomfort (P = 0.09), pain (P = 0.4) or tolerability scores (P = 0.2). Conclusions: A clinically meaningful benefit for this brief mind-body intervention during prostate biopsy is unlikely. Robust patient enrollment is feasible using 2-stage consent.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Biopsy
653 a Mindfulness
653 a Prostate
653 a Randomized controlled trial
7001 a Vertosick, Emily A.4 aut
7001 a Carlsson, Sigrid Vu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology4 aut
7001 a Lin, Xin4 aut
7001 a Wolchasty, Natalie4 aut
7001 a Hardbattle, Robin4 aut
7001 a Vickers, Andrew J.4 aut
7001 a Ehdaie, Behfar4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för urologi4 org
7730 t Urologic Oncology: Seminars and Original Investigationsg 41:12q 41:12x 1078-1439x 1873-2496
8564 8u https://gup.ub.gu.se/publication/332941
8564 8u https://doi.org/10.1016/j.urolonc.2023.09.016

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